Comparative analysis of mutational hotspots in the spike protein of SARS-CoV-2 isolates from different geographic origins
Graphical abstract
Abbreviations
COVID-19
Coronavirus disease
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
S
Spike
E
envelope
M
membrane
N
nucleocapsid
RdRp
RNA-dependent RNA polymerase
RT-qPCR
reverse transcriptase-quantitative polymerase chain reaction
CT
cycle threshold
ACE2
angiotensin-converting enzyme-2
TMPRSS2
transmembrane serine protease2
Nsp3
nonstructural protein
Orf
open reading frame
RDB
receptor-binding domain
NGS
next-generation sequencing
Keywords
SARS-CoV-2
Spike protein
Spike gene
Mutational hotspots
D614G mutation
Different geographic origins
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