COVID-19 patients with hypothyroidism: a retrospective cohort study from a dedicated COVID hospital of Mumbai, India

Authors

  • Chinmay N. Gokhale Department of Community Medicine, HBTMC and Dr RNCH, Mumbai, Maharashtra, India
  • Smita S. Chavhan Department of Community Medicine, HBTMC and Dr RNCH, Mumbai, Maharashtra, India
  • Balkrishna B. Adsul Department of Community Medicine, HBTMC and Dr RNCH, Mumbai, Maharashtra, India
  • Maharudra A. Kumbhar MCGM run Seven Hills Dedicated COVID Hospital, Mumbai, Maharashtra, India
  • Kirti V. Kinge Department of Community Medicine, HBTMC and Dr RNCH, Mumbai, Maharashtra, India
  • Prasad T. Dhikale Department of Community Medicine, HBTMC and Dr RNCH, Mumbai, Maharashtra, India
  • Aniket R. Ingale Department of Community Medicine, HBTMC and Dr RNCH, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20211228

Keywords:

Hypothyroidism, COVID19, COVID-19 outcome

Abstract

Background: India was one of the leaders in terms of COVID-19 cases across year 2020. Hypothyroidism is one of the common morbidities that may influence prognosis of infectious diseases. However, some previously published literature had suggested that hypothyroidism may not be affecting outcomes of COVID-19 disease. Objective of this study was to analyze the outcomes of COVID-19 patients with pre-existing hypothyroidism and further suggesting determinants of worse outcomes

Methods: This retrospective cohort study was carried out at one of largest Dedicated COVID-19 Hospital in Mumbai, India. Of the 16306 patients that got admitted at this hospital in year 2020, all those having hypothyroidism were included. Bivariate analysis was performed using Chi-square test and Multivariate analysis was performed using multiple logistic regression.

Results: A total of 251 patients were having pre-existing hypothyroidism (1.54%). More females had hypothyroidism (73.7%) while death rate was more in males (26.3%). ICU admissions (27.5%) and death proportions (18.3%) were significantly more in hypothyroidism. Diabetes and hypertension were common concomitant Co-morbidities and odds ratios for death for diabetes group, hypertension group and diabetes+hypertension group were 4.9, 8.1 and 4.4 respectively in comparison to those having exclusive hypothyroidism.

Conclusions: This study deals with an important topic of co-existing Hypothyroidism in COVID-19 patients and we can conclude that patients with Hypothyroidism must be considered to be at risk of severe outcomes. Furthermore, age, male gender and presence of concomitant Co-morbidities increase the risk of worse outcome.

Author Biographies

Chinmay N. Gokhale, Department of Community Medicine, HBTMC and Dr RNCH, Mumbai, Maharashtra, India

ASSISTANT PROFESSOR, COMMUNITY MEDICINE

Smita S. Chavhan, Department of Community Medicine, HBTMC and Dr RNCH, Mumbai, Maharashtra, India

ASSOCIATE PROFESSOR, COMMUNITY MEDICINE & DEAN (ADDL.), SEVEN HILLS DCH

Balkrishna B. Adsul, Department of Community Medicine, HBTMC and Dr RNCH, Mumbai, Maharashtra, India

PROFESSOR, COMMUNITY MEDICINE & DEAN, SEVEN HILLS, DCH

Maharudra A. Kumbhar, MCGM run Seven Hills Dedicated COVID Hospital, Mumbai, Maharashtra, India

OSD, MCGM, SEVEN HILLS DCH

Kirti V. Kinge, Department of Community Medicine, HBTMC and Dr RNCH, Mumbai, Maharashtra, India

ASSISTANT PROFESSOR

Prasad T. Dhikale, Department of Community Medicine, HBTMC and Dr RNCH, Mumbai, Maharashtra, India

ASSISTANT PROFESSOR, COMMUNITY MEDICINE

Aniket R. Ingale, Department of Community Medicine, HBTMC and Dr RNCH, Mumbai, Maharashtra, India

STATISTICIAN & ASSISTANT PROFESSOR, COMMUNITY MEDICINE

References

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Published

2021-03-25

How to Cite

Gokhale, C. N., Chavhan, S. S., Adsul, B. B., Kumbhar, M. A., Kinge, K. V., Dhikale, P. T., & Ingale, A. R. (2021). COVID-19 patients with hypothyroidism: a retrospective cohort study from a dedicated COVID hospital of Mumbai, India. International Journal Of Community Medicine And Public Health, 8(4), 1752–1756. https://doi.org/10.18203/2394-6040.ijcmph20211228

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Original Research Articles