Elsevier

Vaccine

Volume 40, Issue 34, 12 August 2022, Pages 4929-4932
Vaccine

Short communication
Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern

https://doi.org/10.1016/j.vaccine.2022.07.013Get rights and content
Under a Creative Commons license
open access

Abstract

The ongoing SARS-CoV-2 pandemic continues to pose an enormous health challenge globally. The ongoing emergence of variants of concern has resulted in decreased vaccine efficacy necessitating booster immunizations. This was particularly highlighted by the recent emergence of the Omicron variant, which contains over 30 mutations in the spike protein and quickly became the dominant viral strain in global circulation. We previously demonstrated that delivery of a SARS-CoV-2 subunit vaccine via a high-density microarray patch (HD-MAP) induced potent immunity resulting in robust protection from SARS-CoV-2 challenge in mice. Here we show that serum from HD-MAP immunized animals maintained potent neutralisation against all variants tested, including Delta and Omicron. These findings highlight the advantages of HD-MAP vaccine delivery in inducing high levels of neutralising antibodies and demonstrates its potential at providing protection from emerging viral variants.

Keywords

Microarray patch
SARS-CoV-2
COVID-19
Vaccine

Data availability

Data will be made available on request.

Cited by (0)

1

These authors have contributed equally to this work and share first authorship.