Issue 12, 2020

Understanding the relationship between viral infections and trace elements from a metallomics perspective: implications for COVID-19

Abstract

Recently, the World Health Organization (WHO) declared a pandemic situation due to a new viral infection (COVID-19) caused by a novel virus (Sars-CoV-2). COVID-19 is today the leading cause of death from viral infections in the world. It is known that many elements play important roles in viral infections, both in virus survival, and in the activation of the host's immune system, which depends on the presence of micronutrients to maintain the integrity of its functions. In this sense, the metallome can be an important object of study for understanding viral infections. Therefore, this work presents an overview of the role of trace elements in the immune system and the state of the art in metallomics, highlighting the challenges found in studies focusing on viral infections.

Graphical abstract: Understanding the relationship between viral infections and trace elements from a metallomics perspective: implications for COVID-19

Article information

Article type
Critical Review
Submitted
22 Sep 2020
Accepted
13 Nov 2020
First published
14 Nov 2020

Metallomics, 2020,12, 1912-1930

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