Immunity
Volume 54, Issue 2, 9 February 2021, Pages 205-210
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Primer
B cell memory: understanding COVID-19

https://doi.org/10.1016/j.immuni.2021.01.014Get rights and content
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Immunological memory is a mechanism to protect us against reinfection. Antibodies produced by B cells are integral to this defense strategy and underlie virtually all vaccine success. Here, we explain how B cell memory is generated by infection and vaccination, what influences its efficacy and its persistence, and how characterizing these parameters in the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will help achieve protective immunity through vaccination.

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