Insulin resistance (IR) may be a potential key factor for COVID-19 severity but in Indonesia itself, there is no data regarding relationship between insulin resistance and COVID-19 severity, especially those using HOMA IR examination.The aim of this research is to determine correlation between insulin resistance and COVID-19 severity in type 2 Diabetes Mellitus patients. This research was a cross-sectional analytic design with prospective data collection from medical records who were hospitalized in isolation room at Haji Adam Malik Hospital Medan from June 2021 – September 2021 on patients diagnosed with COVID-19 with comorbid diabetes mellitus who met inclusion and exclusion criteria. For analysis of insulin resistance based on HOMA-IR score with COVID-19 severity based on clinical manifestations (mild, moderate, severe, and critical), a chi square test was performed and assumed to be significant if p value <0.05. The majority of research subjects had HOMA-IR score >3.8 as many as 35 people, 21 people (60.0%) of whom were severe COVID-19 and 8 people (22.9%) were moderate COVID-19, 6 people (17.1%) were critical degrees COVID-19. The research subjects who had a HOMA-IR score <2.6 as many as 32 people, 24 people (75.0%) of whom were moderate COVID-19, 7 people (21.9%) were severe COVID-19 and 1 person (3.1%) were critical degree COVID-19. The research subjects who had a HOMA-IR score of 2.6-3.8 were 7 people, 4 people (57.1%) of whom were moderate COVID-19, 2 people (28.6%) were severe COVID-19 degrees and 1 person (14.3%) were critical degree COVID-19. There is a statistically significant correlation between HOMA-IR score and COVID-19 severity

COVID-19

insulin resistance

type 2 diabetes mellitus

HOMA-IR