The Innovation
Volume 2, Issue 4, 28 November 2021, 100159
ArticleHost-specific asymmetric accumulation of mutation types reveals that the origin of SARS-CoV-2 is consistent with a natural process
Under a Creative Commons license
open access
Public summary
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The asymmetric de novo mutations in SARS-CoV-2 are induced by mutagenic mechanisms in the host cellular environment
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De novo mutations determine the molecular spectrum of accumulated mutations during SARS-CoV-2 evolution
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Molecular spectra of accumulated mutations in betacoronaviruses cluster according to the host species instead of the phylogenetic relationship
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The mutations accumulated in SARS-CoV-2 prior to its transmission to humans are consistent with an evolutionary process in a bat host
Graphical abstract
Keywords
SARS-CoV-2
molecular spectrum
de novo mutations
mutational signature
evolutionary origin
mRNA mutation
Cited by (0)
- 3
These authors contributed equally
© 2021 The Author(s).