Generic placeholder image

Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Clinical Trial

Clinical Value of COVID-19 Chest Radiography and High-Resolution CT Examination

Author(s): Dan Wang, Yalei Shang, Yuehua Chen, Jianguo Xia, Weizhong Tian*, Tao Zhang*, Hui Dai* and Yonggang Li*

Volume 18, Issue 7, 2022

Published on: 24 March, 2022

Article ID: e291221199614 Pages: 7

DOI: 10.2174/1573405618666211229143121

Price: $65

Abstract

Background: Novel coronavirus disease 2019 (COVID-19) pneumonia remains a matter of concern. Chest CT findings of COVID-19 pneumonia have been reported widely, while there is relatively rare research on chest X-ray (CXR).

Objective: The study was aimed to compare the CXR and chest CT findings of patients with confirmed COVID-19 infection and to explore their respective clinical values.

Methods: 28 inpatients with COVID-19 pneumonia who underwent both CXR and CT were included. The pulmonary manifestations of the lesions were recorded. Ground-glass opacity (GGO), consolidation, and fibrosis were quantified in CXR and chest CT separately. Consistency was analyzed using Fleiss' kappa and intraclass correlation coefficient. The stages of the disease in CXR and chest CT were evaluated.

Results: Approximately 67.9% (19/28) of subjects had abnormal findings on CXR. The common manifestations in CXR were ground-glass opacities (GGO) (100%, 19/19) and consolidation (68.4%, 13/19). 92.9% (26/28) of patients had abnormal manifestations on CT. The common manifestations in CT were GGO (88.5%, 23/26), consolidation (69.2%, 18/26), reticular opacity (69.2%, 18/26) and nodule (46.2%, 12/26). Among the abnormalities between CXR and CT, only consolidation was consistent (κ=0.510). GGO (ICC=0.501) and consolidation (ICC=0.431) scores were consistent in CXR and chest CT. The results of staging were the same in 14 cases, most of them were in stage I and stage II. While in other cases with inconsistent results, CT was more advanced in the disease stage than CXR, mainly stage III and stage IV.

Conclusion: CXR is helpful to observe the change of the pulmonary lesions in patients with confirmed COVID-19 pneumonia. CT can be used for early diagnosis and staging of lesions.

Keywords: SARS-CoV-2, COVID-19, chest X-ray (CXR), CT, consistency, clinical value.

Graphical Abstract
[1]
Dai H, Zhang X, Xia J, et al. High-resolution chest CT features and clinical characteristics of patients infected with COVID-19 in Jiangsu, China. Int J Infect Dis 2020; 95: 106-12.
[http://dx.doi.org/10.1016/j.ijid.2020.04.003] [PMID: 32272262]
[2]
Wasilewski PG, Mruk B, Mazur S, Półtorak-Szymczak G, Sklinda K, Walecki J. COVID-19 severity scoring systems in radiological imaging - a review. Pol J Radiol 2020; 85: e361-8.
[http://dx.doi.org/10.5114/pjr.2020.98009] [PMID: 32817769]
[3]
Chung M, Bernheim A, Mei X, et al. CT imaging features of 2019 novel coronavirus (2019-nCoV). Radiology 2020; 295(1): 202-7.
[http://dx.doi.org/10.1148/radiol.2020200230] [PMID: 32017661]
[4]
Hansell DM, Bankier AA, MacMahon H, McLoud TC, Müller NL, Remy J. Fleischner Society: Glossary of terms for thoracic imaging. Radiology 2008; 246(3): 697-722.
[http://dx.doi.org/10.1148/radiol.2462070712] [PMID: 18195376]
[5]
Ng CK, Chan JW, Kwan TL, et al. Six month radiological and physiological outcomes in severe acute respiratory syndrome (SARS) survivors. Thorax 2004; 59(10): 889-91.
[http://dx.doi.org/10.1136/thx.2004.023762] [PMID: 15454656]
[6]
Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet 2020; 395(10223): 507-13.
[http://dx.doi.org/10.1016/S0140-6736(20)30211-7] [PMID: 32007143]
[7]
Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020; 382(8): 727-33.
[http://dx.doi.org/10.1056/NEJMoa2001017] [PMID: 31978945]
[8]
Sun P, Lu X, Xu C, Sun W, Pan B. Understanding of COVID-19 based on current evidence. J Med Virol 2020; 92(6): 548-51.
[http://dx.doi.org/10.1002/jmv.25722] [PMID: 32096567]
[9]
Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003; 348(20): 1953-66.
[http://dx.doi.org/10.1056/NEJMoa030781] [PMID: 12690092]
[10]
de Groot RJ, Baker SC, Baric RS, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group. J Virol 2013; 87(14): 7790-2.
[http://dx.doi.org/10.1128/JVI.01244-13] [PMID: 23678167]
[11]
Swerdlow DL, Finelli L. Preparation for possible sustained transmission of 2019 novel coronavirus: Lessons from previous epidemics. JAMA 2020; 323(12): 1129-30.
[http://dx.doi.org/10.1001/jama.2020.1960] [PMID: 32207807]
[12]
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395(10223): 497-506.
[http://dx.doi.org/10.1016/S0140-6736(20)30183-5] [PMID: 31986264]
[13]
Fu L, Wang B, Yuan T, et al. Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis. J Infect 2020; 80(6): 656-65.
[http://dx.doi.org/10.1016/j.jinf.2020.03.041] [PMID: 32283155]
[14]
Wu Z, McGoogan JM. Characteristics of and important lessons from the Coronavirus Disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA 2020; 323(13): 1239-42.
[http://dx.doi.org/10.1001/jama.2020.2648] [PMID: 32091533]
[15]
Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med 2020; 180(7): 934-43.
[http://dx.doi.org/10.1001/jamainternmed.2020.0994] [PMID: 32167524]
[16]
Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020; 323(11): 1061-9.
[http://dx.doi.org/10.1001/jama.2020.1585] [PMID: 32031570]
[17]
Umakanthan S, Sahu P, Ranade AV, et al. Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID-19). Postgrad Med J 2020; 96(1142): 753-8.
[PMID: 32563999]
[18]
Lan L, Xu D, Ye G, et al. Positive RT-PCR test results in patients recovered from COVID-19. JAMA 2020; 323(15): 1502-3.
[http://dx.doi.org/10.1001/jama.2020.2783] [PMID: 32105304]
[19]
Kang H, Wang Y, Tong Z, Liu X. Retest positive for SARS-CoV-2 RNA of “recovered” patients with COVID-19: Persistence, sampling issues, or re-infection? J Med Virol 2020; 92(11): 2263-5.
[http://dx.doi.org/10.1002/jmv.26114] [PMID: 32492212]
[20]
Zu ZY, Jiang MD, Xu PP, et al. Coronavirus Disease 2019 (COVID-19): A perspective from China. Radiology 2020; 296(2): E15-25.
[http://dx.doi.org/10.1148/radiol.2020200490] [PMID: 32083985]
[21]
Bernheim A, Mei X, Huang M, et al. Chest CT findings in coronavirus disease-19 (COVID-19): Relationship to duration of infection. Radiology 2020; 295(3): 200463.
[http://dx.doi.org/10.1148/radiol.2020200463] [PMID: 32077789]
[22]
Shi H, Han X, Jiang N, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: A descriptive study. Lancet Infect Dis 2020; 20(4): 425-34.
[http://dx.doi.org/10.1016/S1473-3099(20)30086-4] [PMID: 32105637]
[23]
Pan Y, Guan H, Zhou S, et al. Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): A study of 63 patients in Wuhan, China. Eur Radiol 2020; 30(6): 3306-9.
[http://dx.doi.org/10.1007/s00330-020-06731-x] [PMID: 32055945]
[24]
Xie X, Zhong Z, Zhao W, Zheng C, Wang F, Liu J. Chest CT for typical Coronavirus Disease 2019 (COVID-19) pneumonia: Relationship to negative RT-PCR testing. Radiology 2020; 296(2): E41-5.
[http://dx.doi.org/10.1148/radiol.2020200343] [PMID: 32049601]
[25]
Shang Y, Xu C, Jiang F, et al. Clinical characteristics and changes of chest CT features in 307 patients with common COVID-19 pneumonia infected SARS-CoV-2: A multicenter study in Jiangsu, China. Int J Infect Dis 2020; 96: 157-62.
[http://dx.doi.org/10.1016/j.ijid.2020.05.006] [PMID: 32423888]
[26]
Böger B, Fachi MM, Vilhena RO, Cobre AF, Tonin FS, Pontarolo R. Systematic review with meta-analysis of the accuracy of diagnostic tests for COVID-19. Am J Infect Control 2021; 49(1): 21-9.
[http://dx.doi.org/10.1016/j.ajic.2020.07.011] [PMID: 32659413]
[27]
Borghesi A, Maroldi R. COVID-19 outbreak in Italy: experimental chest X-ray scoring system for quantifying and monitoring disease progression. Radiol Med (Torino) 2020; 125(5): 509-13.
[http://dx.doi.org/10.1007/s11547-020-01200-3] [PMID: 32358689]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy