Maryam Rafiq, Ayesha Siddiqa, Sara Khan, Farah Hanif, Sibgha, Muhammad Waseem Bashir

CRP as a Prognostic Indicator in Hospitalized Patients with Covid-19

Maryam Rafiq, Ayesha Siddiqa, Sara Khan, Farah Hanif, Sibgha, Muhammad Waseem Bashir



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ABSTRACT

Objective: The aim of this study is to determine the CRP as a prognostic indicator in hospitalized patients with

COVID-19.

Study Design: Retrospective observational study

Place and Duration: Sahiwal Medical College, Sahiwal. Jan 2021-Nov 2021

Methods: There were ninety patients had coronavirus disease of both genders were presented in this study.

Patients were aged between 20-75 years were admitted in hospital. Informed written consent was taken from all

the patients for detailed demographics age, sex, body mass index, education status and residency. Symptoms

and comorbidities were calculated among all patients. Outcomes were CRP level was indicated among severe,

non-severe and died patients with pandemic disease. Hospital stay was also calculated. Chi square and test was

used for categorical variables. SPSS 22.0 version was used to analyze complete data.

Results: Mean age of the patients was 50.12±3.45 years with mean BMI 27.88±6.34 kg/m2. Majority of the

patients 55 (61.1%) were males and 35 (38.9%) were females. 52 (57.8%) cases were from urban areas and 38

(42.2%) were from rural areas. 49 (54.4%) patients were literate. Fever, dry cough and fatigue were the most

common symptoms in patients. Hypertension and diabetes mellitus were the most common comorbidity. Among

90 cases, rate of mortality was 19 (21.1%). We found that mean CRP level among died patients were significantly

higher 184.11±89.67 mg/L as compared to severe patients 134.13±111.14 mg/L and non-severe patients

89.34±64.43 mg/L. Mean hospital stay was 6.09±6.34 days.

Conclusion: According to our findings, CRP levels rise rapidly in COVID-19 patients, and these data suggest that

CRP could be used clinically to predict COVID-19 prognosis and severity before disease progression and the

manifestation of clinical symptoms. CRP is an acute-phase, non-specific serological biomarker of inflammation

and infection and is linked to disease severity and outcomes.

Keywords: Coronavirus, C-reaction protein (CRP), Outcomes, Mortality



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