ReviewDetection and quantification of Covid-19 antiviral drugs in biological fluids and tissues
Graphical abstract
Keywords
SARS-CoV-2
Antivirals
Analytical methods
Biological matrices
Mass spectrometry
Liquid chromatography
Abbreviations
ACN
acetonitrile
AD
absolute deviation
ADME
adsorption, distribution, metabolism, and elimination
BeWos
human placental choriocarcinoma trophobplast cells
CE
capillary electrophoresis
CHCA
α-cyano-4-hydroxycinnamic acid
CRMs
certified reference materials
CSF
cerebrospinal fluid
CV
coefficient of variation
DEV
deviation from nominal concentration value
DHB
2,5-dihydroxybenzoic acid
d-SPE
dispersive-sold-phase extraction
EMA
European Medicines Agency
Err
absolute value of the relative error
ESI
electrospray ionization
FDA
Food and Drug Administration
FL
fluorescence
HILIC
hydrophilic interaction liquid chromatography
HLB
hydrophilic-lipophilic balance
ICH
International Conference on Harmonization
LC
liquid chromatography
LLE
liquid-liquid extraction
LOD
limit of detection
LLOQ
lower limit of quantification
LOQ
limit of quantification
MALDI
matrix-assisted laser desorption/ionization
MCX
mixed-mode cationic exchange
MLC
micellar liquid chromatography
MRM
Muliple Reaction Monitoring
MSI
MALDI-MS Imaging
MTBE
methyltertbutyl ether
MS
mass spectrometry
NRTIs
nucleoside reverse transcriptase inhibitors
OSP
oseltamivir phosphate
PBA
phenylboronic acid
PBMCs
peripheral blood mononuclear cells
Ph. Eur
European Pharmacopoeia
PIs
protease inhibitors
PMA
phosphomolybdic acid
PP
protein precipitation
PSA
primary-secondary amine
Q
QuEChERS
QC
quality control
Q-MSI
quantitative MALDI-MS Imaging
RdRpIs
RNA polymerase inhibitors
RE
relative error
RSD
relative standard deviation
SDS
sodium dodecyl sulfate
SPE
solid-phase extraction
SRM
Selected Reaction Monitoring
TDM
therapeutic drug monitoring
TCA
trichloroacetic acid
UAE
ultrasound assisted extraction
UHPLC
ultra-high performance liquid chromatography
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