Particularities of immunological reactivity, nitric oxide and its metabolities production in patients with pulmonary tuberculosis in association with covid-19 infection

Authors

  • Serghei Ghinda ISMP Institutul de Ftiziopneumologie „Chiril Draganiuc”, Chişinău, R. Moldova
  • Elena Tudor ISMP Institutul de Ftiziopneumologie „Chiril Draganiuc”, Chişinău, R. Moldova
  • Tatiana Osipov IP Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, R. Moldova
  • Valentina Chirosca
  • Valeriana Pantea IP Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, R. Moldova
  • Zinaida Ciobanu ISMP Institutul de Ftiziopneumologie „Chiril Draganiuc”, Chişinău, R. Moldova
  • Galina Crivenco ISMP Institutul de Ftiziopneumologie „Chiril Draganiuc”, Chişinău, R. Moldova
  • Valentin Gudumac IP Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, R. Moldova

DOI:

https://doi.org/10.52692/1857-0011.2021.1-69.13

Keywords:

pulmonary tuberculosis, immunology, biochemistry

Abstract

The study included 24 patients, which formed the baseline group — 12 patients with pulmonary tuberculosis in combination with COVID-19 infection and the control group — 12 patients with pulmonary tuberculosis. There were studied the leukocyte formula, the content of CD3, CD4, CD8 lymphocytes, the content of NO2-+NO3- total and its metabolites. The obtained results showed that in patients with pulmonary tuberculosis and COVID-19 there is a pronounced decrease of lymphocytes and an unexpressed shift of the leukocyte formula to the left. The lymphocyte content decreases due to CD3 lymphocytes and their subpopulation of CD4 (helper) lymphocytes. The CD4/CD8 immunoregulatory index demonstrates a stimulation of immunological reactivity in patients with pulmonary tuberculosis and depression of immunological reactivity in patients with pulmonary tuberculosis in combination with COVID-19 infection and a pronounced suppression of the production content of NO2-+NO3- total and its metabolites (NO2- and NO3-)

Author Biographies

Serghei Ghinda, ISMP Institutul de Ftiziopneumologie „Chiril Draganiuc”, Chişinău, R. Moldova

dr. hab. în şt. med., prof. cercet

Elena Tudor, ISMP Institutul de Ftiziopneumologie „Chiril Draganiuc”, Chişinău, R. Moldova

dr. în şt. med., conf. cercet., membru-coresp. AŞMM

Galina Crivenco, ISMP Institutul de Ftiziopneumologie „Chiril Draganiuc”, Chişinău, R. Moldova

dr. în şt. med., conf. cercet

Valentin Gudumac, IP Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, R. Moldova

dr. hab. în şt. med., prof. univer

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Published

2021-05-11

Issue

Vol. 69 No. 1 (2021): Medical Sciences

Section

Research Article

License

Copyright (c) 2021 Bulletin of the Academy of Sciences of Moldova. Medical Sciences

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This work is licensed under a Creative Commons Attribution 4.0 International License.