感染症学雑誌
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
症例
SARS-CoV-2 PCR 検査が長期陽性持続した新型コロナウイルス感染症(COVID-19)の2 例
加藤 英明渡邊 弘樹小林 信明原 悠酒井 和也中嶋 賢人小川 史洋佐野 加代子山崎 悦子宇宿 修三田中 伸子竹内 一郎中島 秀明金子 猛
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2020 年 94 巻 4 号 p. 591-595

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Real-time polymerase chain reaction (RT-PCR) assay is used for the diagnosis of novel coronavirus disease 2019 (COVID-19), and for identifying those patients with COVID-19 who have recovered but may require ongoing isolation. We report two cases of COVID-19 in whom the RT-PCR test remained persistently positive until 16 and 19 days after resolution of the symptoms (33 and 28 days after the onset of symptoms), respectively. While the viral load in the respiratory specimens had decreased after resolution of the symptoms, the RT-PCR test result continued to be positive. Mucoid sputum samples obtained by handing containers to the patient returned positive results for even longer periods than nasal swab samples. Our findings have led us to question the usefulness of the RT-PCR assay for determining the appropriate time to release patients from isolation after they show symptomatic recovery. RT-PCR performed using mucoid sputum samples was also sensitive and safe, because of the low exposure of the healthcare workers to the virus while collecting the test samples.
Both authors contributed equally to this study.

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© 2020 一般社団法人 日本感染症学会
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