Comorbidities increase the risk of severity and mortality in COVID-19 patients: a systematic review and meta-analysis
DOI:
https://doi.org/10.33448/rsd-v10i2.12533Keywords:
Coronavirus; COVID-19; Comorbidities; Chronic disease; SARS-CoV-2.Abstract
Introduction: Several studies have shown that patients with comorbidities present a poor clinical outcome of COVID-19, but the conclusions are not yet consolidated. We conducted a meta-analysis to evaluate the relationship between the preexistent conditions (comorbidities) in patients infected with SARS-CoV-2 and the outcome of COVID-19. Methods: PubMed, Science Direct, ISI Web of Science and Scopus databases were examined up to November 2020. We calculated the pooled odds ratio (OR) with 95% confidence interval, using fixed-effects or random-effects models. Results: A total of 48 retrospective cohort studies with 344,290 COVID-19 patients were included in the meta-analysis. The pooled results showed that hypertension, diabetes, cardiovascular, chronic pulmonary, chronic kidney and cerebrovascular diseases increase the risk of severity and mortality in COVID-19 patients. Moreover, malignancy was associated with an increased risk of death from COVID-19. Conclusions: The comorbidities previously mentioned may be important predictors of poor outcome of COVID-19, contributing to the prognosis of severe cases of the disease.
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Copyright (c) 2021 Edilson Leite de Moura; Jean Moises Ferreira; Ana Caroline Melo dos Santos ; Denise Macedo da Silva ; Maria Lidiane Ferreira da Silva ; Gleyce Kelly Marques de Oliveira Silva; Pedro Henrique Nobre Silva ; José Anderson dos Santos; Marcos Antônio da Silva Barbosa Junior ; Abel Barbosa Lira Neto ; Aline Cristine Pereira e Silva; Carlos Alberto de Carvalho Fraga; Karol Fireman de Farias; Elaine Virginia Martins de Souza Figueiredo
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