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Open Letter

COVID-19 vaccine delivery: an opportunity to set up systems for the future

[version 1; peer review: 2 approved with reservations]
PUBLISHED 18 Dec 2020
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This article is included in the Coronavirus (COVID-19) collection.

Abstract

The race to develop safe and effective SARS-COV-2 vaccines has moved with unprecedented speed. There are now multiple promising candidates seeking emergency use authorization from the United States Food and Drug Administration and a host of candidates positioned for approval worldwide. Attention has now turned to allocation, distribution and verification of these vaccines, yet this focus exposes that the underlying infrastructure for global delivery and monitoring is threadbare and unevenly distributed. This presents both a barrier and an opportunity to deploy sustainable infrastructure. Major global stakeholders must convene quickly, collaborate, and collectively invest in global standards, legal models, common vocabularies and interoperable biometric-supported digital health technologies. As the COVID-19 vaccine effort scales, governments, private sector and NGOs have the chance to place lasting resources needed for equitable and effective delivery that can pay dividends into the future.

Keywords

vaccine deliver, biometrics, identity, immunizations, health systems strengthening, health service deliver, COVID-19, COVID-19 vaccine, SARS-COV-2 vaccine, SARS-COV-2

As we get closer and closer to an effective SARS-CoV-2 vaccine, policymakers, academics, and scientists around the globe are turning their attention to yet another fundamental challenge - how will governments monitor and verify vaccine delivery.

An effective vaccination program will falter if we don’t invest in the information infrastructure for vaccine delivery in developed and low and middle-income countries alike. There is little evidence that we are ready for this. Glaring data gaps exist at numerous levels of global identity and health information exchange. Data on routine immunization already faces deep challenges. Studies show, for example, that despite WHO coverage estimates near 99%, up to 54% of children do not actually receive timely measles vaccinations in Bangladesh1. Widespread gaps in data quality, reporting, and patient identification in routine vaccine delivery disrupt services and presage COVID-19 vaccine delivery challenges in the near future.

The supply of the first generation COVID-19 vaccines will be scarce, and each course must reach the intended recipient. Corruption, leakage, spoilage and even accidental duplications are deadly. Most current COVID-19 vaccine candidates require a two-dose course; patients will need to be reliably identified to ensure appropriate spacing of doses. Further, long-term efficacy remains to be seen and will require accurate, longitudinal patient data. Tracking patient data over time and across service delivery points requires patient identification systems. Patient identification systems will be the hardest to achieve in the places they are needed most. Many low-income countries lack a foundational government-issued ID. About one billion people lack any official civil registration.

We do have some options to face this disturbing scenario and one involves biometric digital identity.

The foundational ID challenge will not be solved in time for the release of a COVID-19 vaccine. However, organizations like Gavi have identified biometric digital identity as a potential lever to bridge the identity gap and ensure accurate data2. Done properly, these systems can be privacy preserving, interoperable, portable, secure, and capable of serving both adult and children's needs. Interoperability standards will ensure these systems can plug into foundational ID programs as coverage expands over the next decade, and privacy-first architecture design is already underway in several projects3.

Biometric immunization registries can deliver both COVID-19 vaccines and serve routine immunizations which are becoming less routine as the pandemics secondary effects become more prominent. We should be developing these architectures now - months before the ramp up of vaccine delivery begins and before further lapses in basic primary health lead to explosions of other vaccine preventable illnesses. Missing this chance could waste significant time, effort, and the chance to build forward-looking infrastructure that serves basic healthcare long into the future.

During the latest Ebola epidemic, a rush of technologies were hastily assembled to track and combat the disease, leading to massive duplication of efforts and half-built tools that were abandoned after the crisis4.

We know what is coming. In the next quarter all attention will be on the allocation, distribution and verification of COVID-19 vaccine delivery. Routine immunizations will be disrupted. Investing in the infrastructure that can support COVID-19 vaccine delivery and routine immunizations, for everyone young and old, can ensure that we are taking advantage of this opportunity amidst the challenges and putting countries on track to fight not only this pandemic, but pressing public health needs for years to come.

Major global stakeholders must convene, collaborate, and collectively invest in global standards, legal infrastructure, common vocabularies and interoperable biometrically-supported digital health technologies. This will pay dividends long after the world’s attention has shifted. If done transparently, this infrastructure can enhance trust in vaccines, something critical to clinical trial enrolment and widespread public adoption.

We have a narrow opportunity to set the stage for fair and sustainable infrastructure across the globe. If done well, we can ensure the promise of the COVID-19 vaccine portfolio leads to future widespread vaccination - and protection - for global populations.

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Version 2
VERSION 2 PUBLISHED 18 Dec 2020
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CITE
how to cite this article
Weintraub R, Plotkin S, Liu M et al. COVID-19 vaccine delivery: an opportunity to set up systems for the future [version 1; peer review: 2 approved with reservations] Gates Open Res 2020, 4:182 (https://doi.org/10.12688/gatesopenres.13210.1)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Open Peer Review

Current Reviewer Status: ?
Key to Reviewer Statuses VIEW
ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions
Version 1
VERSION 1
PUBLISHED 18 Dec 2020
Views
29
Cite
Reviewer Report 20 Jan 2021
Alan Gelb, Center for Global Development, Washington, DC, USA 
Approved with Reservations
VIEWS 29
The paper addresses an important issue: the pace of Covid-19 vaccine deployment is outstripping the data systems needed to manage and document it. There is a risk of ending up with multiple, disconnected systems, many of low quality, especially in ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Gelb A. Reviewer Report For: COVID-19 vaccine delivery: an opportunity to set up systems for the future [version 1; peer review: 2 approved with reservations]. Gates Open Res 2020, 4:182 (https://doi.org/10.21956/gatesopenres.14427.r30148)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
Views
34
Cite
Reviewer Report 15 Jan 2021
Kristin Nelson, Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA 
Approved with Reservations
VIEWS 34
This is a timely article that describes a key barrier to successful SARS-CoV-2 vaccine rollout globally – the lack of effective systems to record vaccinations. The authors propose the use of biometric digital identifiers to identify vaccinated individuals and monitor ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Nelson K. Reviewer Report For: COVID-19 vaccine delivery: an opportunity to set up systems for the future [version 1; peer review: 2 approved with reservations]. Gates Open Res 2020, 4:182 (https://doi.org/10.21956/gatesopenres.14427.r30150)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.

Comments on this article Comments (0)

Version 2
VERSION 2 PUBLISHED 18 Dec 2020
Comment
Alongside their report, reviewers assign a status to the article:
Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions

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