Development of a recombinant vaccine containing a spike S1-Fc fusion protein induced protection against MERS-CoV in human DPP4 knockin transgenic mice
Abbreviations
BSL
biosafety level
CEF
chicken embryo fibroblast
CHO
Chinese hamster ovary
ELISA
enzyme-linked immunosorbent assay
Fc
fragment of crystalline
MERS
Middle East respiratory syndrome
MERS-CoV
Middle East respiratory syndrome coronavirus
PBS
phosphate-buffered saline
PBST
phosphate-buffered saline in 0.05 % Tween 20
PCR
polymerase chain reaction
PFU
plaque-forming unit
RBD
receptor-binding domain
RLU
relative light unit
SARS-CoV
severe acute respiratory syndrome coronavirus
SFM
serum-free medium
Keywords
Middle East respiratory syndrome coronavirus
Vaccine development
Immunogenicity
Alum adjuvant
Fragment of crystalline (Fc) molecule
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