Association between SARS-CoV-2 infection and the appearance of oral manifestations: a systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i1.25240

Keywords:

Coronavírus; COVID-19; Oral manifestations.

Abstract

The aim of this qualitative systematic review is to establish the relationship between SARS-CoV-2 infection and the appearance of oral manifestations. The results were obtained after extensive research and review of articles currently published on the subject in question. Studies claim that the mucosa of the oral cavity may be a high-risk route for SARS-CoV-2 infection, raising the hypothesis that lesions may develop in the oral cavity due to the virus infection. The most commonly reported changes are taste disorders such as dysgeusia, hypogeusia and ageusia. Mucous lesions, such as ulcers, erosions, mucositis, blister, macules and plaques, also found in affected patients, varying in quantity, appearance and location. Dry mouth sensation, TMJ disorders and opportunistic fungal and viral infections are reported in some cases. However, the direct cause-and-effect relationship between SARS-CoV-2 infection and the appearance of lesions in the oral cavity is still unclear. Authors defend that the general state of immunosuppression, stress and/or vascular alterations, inherent to COVID-19, may explain the arise these lesions. It is evident, therefore, that there is a relationship between COVID-19 and the development of dental lesions, but further studies are needed to understand the pathogenesis of these alterations.

References

Aghzedeh, N., et al. (2020). Oral vesicles and acral erythema: report of a cutaneous manifestation of COVID-19. International Journal of Dermatology, 59, 1153-1154.

Biadsee, A., et al. (2020). Olfactory and Oral Manifestations of COVID-19: Related Symptoms - A Potential Pathway to Early Diagnosis. Otolaryngology – Head and Neck Surgery, 163(4), 722–728.

Brandão, T. B., et al. (2020). Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ?. Oral Medicine, 131(2), 45-51.

Carreras-Presas, C. M., et al. (2020). Oral vesiculobullous lesions associated with SARS-CoV-2 infection. Oral Diseases, 00, 1-3.

Chaux-Bodard, A.G., et al. (2020). Oral manifestation of Covid-19 as an inaugural symptom?. J Oral Med Oral Surg., 26(18), 1.

Chen, L., et al. (2020). Detection of SARS-CoV-2 in saliva and characterization of oral symptoms in COVID-19 patients. Cell Prolif., 53(12), 1-7.

Corchuelo, J. & Ulloa, F. C. (2020). Oral manifestations in a patient with a history of asymptomatic COVID-19: Case report. International Journal of Infectious Diseases, 100, 154-157.

Filette, J. M. K. (2020) Coronavirus disease 2019-related Kawasaki-like disease in an adult: A case report. JAAD Case Reports, 6(8), 780-782.

Lechien, J. R., et al. (2020). Parotitis-like symptoms associated with COVID-19. Emerging Infectious Diseases, 26 (9), 2270-2271.

Lima, C. M. A. O. (2020). Informações sobre o novo coronavírus (COVID-19). Radiol Bras., 53(2), 5-6.

Lowe, A., et al. (2021). COVID-19-associated herpetic gingivostomatitis. Clinical and Experimental Dermatology., 46, 162–194.

Malih, N., et al. (2020). Unexpected Presentation of COVID-19 in a 38-Year-Old Male Patient: A Case Report. Case Rep Dermatol., 12, 124-131.

Medeiros, R. A., et al. (2020). Prevalence of symptoms of temporomandibular disorders, oral behaviors, anxiety, and depression in Dentistry students during the period of social isolation due to COVID-19. J Appl Oral Sci., 28, 1-8.

Miranda, J. S., et al. (2021). COVID-19 and Painful Temporomandibular Disorders: what does the dentist need to know?. RGO, Rev Gaúch Odontol., 69, 1-7.

Moraes, M. F., et al. (2021). Oral and cutaneous manifestations of covid-19 in pediatric patients. RGO, Rev Gaúch Odontol., 69, 05.

Nuno-Gonzalez, A., et al. (2021). Prevalence of mucocutaneous manifestations in 666 patients with COVID-19 in a field hospital in Spain: oral and palmoplantar findings. Br J Dermatol., 184, 184–5.

Orcina, B. F. & Santos, P.S.S. (2021). Oral manifestation COVID-19 and the rapid resolution of symptoms post-Phtalox treatment: a case series. Int. J. Odontostomat., 15(1), 67-70.

Pedrosa, M. S., et al. (2020). Salivary glands, saliva and oral findings in COVID-19 infection. Pesqui Bras Odontopediatria Clín Integr., 20(1), 1-7.

Rocha, B. A., et al. (2021). Viral enanthema in oral mucosa: A possible diagnostic challenge in the COVID-19 pandemic. Oral Diseases, 27(3), 776-778.

Rodríguez, M. D., et al. (2020). Oral manifestations associated with COVID-19. Oral Diseases, 00, 1-3.

Sandhaus, H., et al. (2020). Association Between COVID-19 and Kawasaki Disease: Vigilance Required From Otolaryngologists. Otolaryngology–Head and Neck Surgery, 163(2), 316–317.

Santos, J. A., et al. (2020). Oral Manifestations in Patients with COVID-19: A Living Systematic Review. Journal of Dental Research, 00(0), 1-14.

Sinadinos, A. & Shelswell, J. (2020). Oral ulceration and blistering in patients with COVID-19. Evidence-Based Dentistry, 21, 49.

Singh, C., et al. (2020). Skin and Mucosal Damage in Patients Diagnosed With COVID-19. J Wound Ostomy Continence Nurs, 47(5), 435-438.

Soares, C. D., et al. (2020). Oral lesions in a patient with Covid-19. Med Oral Patol Oral Cir Bucal., 25, 4.

Tapia, R. O. C., et al. (2020). Oral mucosal lesions in patients with SARS-CoV-2 infection. Report of four cases. Are they a true sign of COVID-19 disease?. Spec Care Dentist., 40, 555-560.

Tomo, S., et al. (2020). Oral mucositis in a SARS-CoV-2-infected patient: Secondary or truly associated condition?. Oral Diseases, 00, 1-5.

Published

12/01/2022

How to Cite

FRANCO, A. G. .; JÚNIOR ELOI, L. .; FRANCO, A. B. G. .; OLIVEIRA, B. J. de . Association between SARS-CoV-2 infection and the appearance of oral manifestations: a systematic review. Research, Society and Development, [S. l.], v. 11, n. 1, p. e46811125240, 2022. DOI: 10.33448/rsd-v11i1.25240. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/25240. Acesso em: 19 apr. 2024.

Issue

Section

Review Article