Elsevier

Chemosphere

Volume 311, Part 2, January 2023, 137005
Chemosphere

Synthesis of active-site rich molybdenum-doped manganese tungstate nanocubes for effective electrochemical sensing of the antiviral drug (COVID-19) nitazoxanide

https://doi.org/10.1016/j.chemosphere.2022.137005Get rights and content

Highlights

  • The Mo doped MnWO4 NCs were prepared by simple and inexpensive hydrothermal synthesis method.

  • A new electrochemical sensor (Mo–MnWO4/GCE) was developed for detection of the COVID-19 drug nitazoxanide (NTZ).

  • The Mo–MnWO4/GCE exhibits good electrocatalytic activity towards NTZ detection in biological samples.

  • A promising sensing device for detection of drugs by exploring the defect engineering on metal tungstates.

Abstract

Nitazoxanide (NTZ), a promising antiviral agent, is currently being tested in clinical trials as a potential treatment for novel coronavirus disease 2019 (COVID -19). This paper describes a one-pot hydrothermal synthesis to prepare molybdenum (Mo)-doped manganese tungstate nanocubes (Mo–MnWO4 NCs) for the electrochemical sensing of NTZ. The as-prepared Mo–MnWO4 NCs were characterized using various techniques such as XRD, Raman, FE-SEM, FE-TEM, and XPS to confirm the crystal structure, morphology, and elemental composition. The obtained results demonstrate that Mo doping on MnWO4 generates many vacancy sites, exhibiting remarkable electrochemical activity. The kinetic parameters of the electrode modified with Mo–MnWO4 NCs were calculated to be (Ks) 1.1 × 10−2 cm2 s−1 and (α) 0.97, respectively. Moreover, a novel electrochemical sensor using Mo–MnWO4 NCs was fabricated to detect NTZ, which is used as a primary antibiotic to control COVID-19. Under optimal conditions, the electrochemical reduction of NTZ was determined with a low detection limit of 3.7 nM for a linear range of 0.014–170.2 μM with a high sensitivity of 0.78 μA μM−1 cm−2 and negligible interference with other nitro group-containing drugs, cations, and anions. The electrochemical sensor was successfully used to detect NTZ in the blood serum and urine samples and achieved high recoveries in the range of 94–99.2% and 95.3–99.6%, respectively. This work opens a way to develop high-performance sensing materials by exploring the introduction of defect engineering on metal tungstates to detect drug molecules for practical applications.

Keywords

Molybdenum
Manganese Tungstate
Nanocubes
COVID-19
Nitazoxanide
Electrochemical sensor

Data availability

Data will be made available on request.

Cited by (0)

1

Ramaraj Sukanya and Sonaimuthu Mohandoss contributed equally to this manuscript.

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