A Longitudinal Study of Humoral Immune Responses Induced by a 3-Dose Inactivated COVID-19 Vaccine in an Observational, Prospective Cohort

16 Pages Posted: 1 Mar 2022

See all articles by Yue Tao

Yue Tao

Nanjing University - The Affiliated Drum Tower Hospital

Mengyin Ma

Nanjing University - Nanjing Drum Tower Hospital

Ming Li

Nanjing University - The Affiliated Drum Tower Hospital

Yu Geng

affiliation not provided to SSRN

Yawen Wan

affiliation not provided to SSRN

Minxin Mao

affiliation not provided to SSRN

Lin Chen

affiliation not provided to SSRN

Ya Shen

affiliation not provided to SSRN

Liguo Zhu

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - Jiangsu Provincial Center for Disease Control and Prevention

Yuxin Chen

affiliation not provided to SSRN

Han Shen

affiliation not provided to SSRN

Abstract

Objective: To quantify the dynamic SARS-CoV-2 specific antibody levels induced by an inactivated COVID-19 vaccine, CoronaVac.

Methods: An observational, prospective cohort study was performed with 93 healthy healthcare workers from a tertiary hospital in Nanjing, China. Serum SARS-CoV-2 specific IgM, IgG, and ACE2-blocking antibodies were measured at seven time points among participants who received 3 doses of inactivated COVID-19 vaccine.

Results: SARS-CoV-2 specific IgG and ACE2-blocking antibody seroconversion rate is high after receiving primary and booster immunization. Besides, vaccine immune responses were negatively correlated with age. Additionally, SARS-CoV-2 specific IgG and ACE-2-blocking antibody titers were highly correlated with neutralization titers of D614G, Omicron, and Delta strain.

Conclusions: CoronaVac elicited robust SARS-CoV-2 specific IgM, IgG and ACE2-blocking antibody responses. Monitoring SARS-CoV-2 antibody responses induced by vaccination would provide important guidance for the immunogenicity evaluation of COVID-19 vaccines.

Note:
Funding Information: This study was supported by Clinical Trials from the Affiliated Drum Tower Hospital, Medical School of Nanjing University (2021-LCYJ-PY-09), Nanjing Important Science & Technology Specific Projects (2021-11005), Nanjing Medical Science and Technique Development Foundation (QRX17141 and YKK19056), Social Development Foundation of Jiangsu Province BE2021739).

Conflict of Interests: The authors have declared that no conflict of interest exists.

Ethical Approval: The study design has been approved by the Ethics Committee of Nanjing Drum Tower Hospital (2021-034-01).

Trial Registration: This study has been registered with ClinicalTrials.gov (NCT04729374).

Keywords: COVID-19, SARS-CoV-2, humoral immune responses, vaccine, booster

Suggested Citation

Tao, Yue and Ma, Mengyin and Li, Ming and Geng, Yu and Wan, Yawen and Mao, Minxin and Chen, Lin and Shen, Ya and Zhu, Liguo and Chen, Yuxin and Shen, Han, A Longitudinal Study of Humoral Immune Responses Induced by a 3-Dose Inactivated COVID-19 Vaccine in an Observational, Prospective Cohort. Available at SSRN: https://ssrn.com/abstract=4046472 or http://dx.doi.org/10.2139/ssrn.4046472

Yue Tao

Nanjing University - The Affiliated Drum Tower Hospital ( email )

321 Zhong Shan Road
Nanjing, Jiangning District 210008
China

Mengyin Ma

Nanjing University - Nanjing Drum Tower Hospital ( email )

Nanjing, 210008
China

Ming Li

Nanjing University - The Affiliated Drum Tower Hospital ( email )

321 Zhong Shan Road
Nanjing, Jiangning District 210008
China

Yu Geng

affiliation not provided to SSRN ( email )

No Address Available

Yawen Wan

affiliation not provided to SSRN ( email )

No Address Available

Minxin Mao

affiliation not provided to SSRN ( email )

No Address Available

Lin Chen

affiliation not provided to SSRN ( email )

No Address Available

Ya Shen

affiliation not provided to SSRN ( email )

No Address Available

Liguo Zhu

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - Jiangsu Provincial Center for Disease Control and Prevention ( email )

Yuxin Chen (Contact Author)

affiliation not provided to SSRN ( email )

No Address Available

Han Shen

affiliation not provided to SSRN ( email )

No Address Available

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