Methods
Electronic databases were searched to identify studies reporting the use of COVID-19 vaccine in IBD. We selected studies reporting the incidence of various adverse effects (local or systemic) and flares of IBD after COVID-19 vaccination. The pooled incidence rates for various adverse effects, stratified for the dose and the type of vaccine (adenoviral or mRNA) were estimated.
Results
Nine studies (16 vaccination cohorts) were included. The pooled incidence rate of overall adverse events was 0.55 (95%CI, 0.45–0.64, I2= 95%). The pooled incidence rate of local adverse events was 0.64 (0.47–0.78, I2= 100%). The pooled incidence rates of fatigue, headache, myalgia, fever and chills were 0.30 (0.21–0.40, I2= 99%), 0.23 (0.17–0.30, I2= 99%), 0.18 (0.13–0.24, I2= 99%), 0.10 (0.06–0.17, I2= 98%) and 0.15 (0.06–0.3, I2= 86%), respectively. The pooled incidence rates of severe adverse events, adverse events requiring hospitalization and flares of IBD following COVID-19 vaccination were 0.02 (0.00–0.12, I2= 97%), 0.00 (0.00–0.01, I2= 27%) and 0.01 (0.01–0.03, I2= 45%), respectively.