Elsevier

The Journal of Pediatrics

Volume 243, April 2022, Pages 214-218.e5
The Journal of Pediatrics

Brief Report
SARS-CoV-2 Spike Protein in Intestinal Cells of a Patient with Coronavirus Disease 2019 Multisystem Inflammatory Syndrome

https://doi.org/10.1016/j.jpeds.2021.11.058Get rights and content

A previously healthy 12-year-old boy had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related multisystem inflammatory syndrome (MIS-C) that was rapidly fatal. Autopsy revealed the presence of a large intracardiac thrombus. SARS-CoV-2 spike protein was detected in intestinal cells, supporting the hypothesis that viral presence in the gut may be related to the immunologic response of MIS-C.

Keywords

COVID-19
inflammation
pathophysiology
autopsy
pathology
kawasaki disease

Abbreviations

MIS-C
Multisystem inflammatory syndrome associated with SARS-CoV-2 infection
PICU
Pediatric intensive care unit
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2

Cited by (0)

C.L.-M. is funded by the Ministerio de Universidades, Spain (Grant FPU18/02965), which had no role in the study design, data analysis, manuscript preparation, or the decision to submit the manuscript. The authors declare no conflicts of interest.

Portions of this study were presented at the European Society of Pediatric and Neonatal Intensive Care, June 15-18, 2021 (virtual).

View Abstract
© 2021 Elsevier Inc. All rights reserved.