Erectile Dysfunction and COVID-19: a Case Report

Authors

  • Gembong Satria Mahardhika Emergency Hospital COVID-19, Wisma Atlet Kemayoran
  • Nastiti Maharani Emergency Hospital COVID-19, Wisma Atlet Kemayoran
  • Theodore Dharma Tedjamartono Emergency Hospital COVID-19, Wisma Atlet Kemayoran
  • Efriadi Ismail Emergency Hospital COVID-19, Wisma Atlet Kemayoran

DOI:

https://doi.org/10.33533/jpm.v15i1.2715

Keywords:

SARS-CoV-2, Impotence, Sexual Dysfunction

Abstract

Coronavirus Diesease-2019 (COVID-19) infection is suspected to affect the sexual behavior and function. The vascular damage related to COVID-19 can affect the impairment of bed blood vessel of penile and finally make the erectile dysfunction (ED). This problem is one of the most common sexual problem in man, with the prevalantion between 13 until 28% at the 40-80 years old, and the incidence increases with higher age. At this time, no data about the effect of COVID-19 to sexual behavior. There was one case of COVID-19 with erectile dysfunction who was treated at Kemayoran Athletes Village COVID-19 hospital. Erectile dysfunction is influenced by several factors; including psychogenic, neurogenic, and infectious. The diagnosis of erectile dysfunction is determined based on the results of history taking and physical examination, using the standard questionnaire (IIEF-5/International index of erectile function-5). A further review is needed to exclude a particular cause, the management can be determined based on the etiology.

References

Leung A, Christ G, Melman A. Physiology of Penile Erection and Pathophysiology of Erectile Dysfunction. Atlas of Male Sexual Dysfunction. 2004;:1-25.

Lewis RW, Fugl-Meyer KS, Corona G, Hayes RD, Laumann EO, Moreira ED, et al. Definitions/epidemiology/risk factors for sexual dysfunction. J Sex Med. 2010;7(4 PART 2):1598–607.

Irwin GM. Erectile Dysfunction. Prim Care - Clin Off Pract [Internet]. 2019;46(2):249–55. Available from: https://doi.org/10.1016/j.pop.2019.02.006

Montorsi F, Briganti A, Salonia A, Rigatti P, Margonato A, Macchi A, et al. Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol. 2003;44(3):360–5.

Montorsi P, Ravagnani PM, Galli S, Briganti A, Salonia A, Dehò F, et al. Association between erectile dysfunction and coronary artery disease: A case report study. J Sex Med. 2005;2(4):575–82.

Montorsi P, Ravagnani PM, Galli S, Rotatori F, Veglia F, Briganti A, et al. Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: The COBRA trial. Eur Heart J. 2006;27(22):2632–9.

Chiurlia E, D’Amico R, Ratti C, Granata AR, Romagnoli R, Modena MG. Subclinical coronary artery atherosclerosis in patients with erectile dysfunction. J Am Coll Cardiol. 2005;46(8):1503–6.

Vlachopoulos C, Rokkas K, Ioakeimidis N, Aggeli C, Michaelides A, Roussakis G, et al. Prevalence of asymptomatic coronary artery disease in men with vasculogenic erectile dysfunction: A prospective angiographic study. Eur Urol. 2005;48(6):996–1003.

Huang CC, Chan WL, Chen YC, Chen TJ, Chung CM, Huang PH, et al. Herpes simplex virus infection and erectile dysfunction: a nationwide population-based study. Andrology. 2013;1(2):240–4.

Farre JM, Fora F, Lasheras MG. Specific aspects of erectile dysfunction in psychiatry. Int J Impot Res. 2004;16(SUPPL. 2):46–9.

Schmidt MH, Schmidt HS. Sleep-related erections: Neural mechanisms and clinical significance. Curr Neurol Neurosci Rep. 2004;4(2):170–8.

Rogers J, Chesney E, Oliver D, Pollak T, McGuire P, Fusar-Poli P et al. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. The Lancet Psychiatry. 2020;7(7):611-627.

Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain, Behavior, and Immunity. 2020;87:18-22.

Desforges M, Le Coupanec A, Dubeau P, Bourgouin A, Lajoie L, Dubé M et al. Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?. Viruses. 2019;12(1):14.

Mazza M, De Lorenzo R, Conte C, Poletti S, Vai B, Bollettini I et al. Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors. Brain, Behavior, and Immunity. 2020;89:594-600.

Speth M, Singer‐Cornelius T, Oberle M, Gengler I, Brockmeier S, Sedaghat A. Mood, Anxiety and Olfactory Dysfunction in COVID ‐19: Evidence of Central Nervous System Involvement?. The Laryngoscope. 2020;130(11):2520-2525.

Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J et al. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. International Journal of Infectious Diseases. 2020;94:55-58.

Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-280.e8.

Coutard B, Valle C, de Lamballerie X, Canard B, Seidah N, Decroly E. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Research. 2020;176:104742.

Ziegler C, Allon S, Nyquist S, Mbano I, Miao V, Tzouanas C et al. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 2020;181(5):1016-1035.e19.

. Singh M, Bansal V, Feschotte C. A single-cell RNA expression map of human coronavirus entry factors. 2020;.

Butowt R, Bilinska K. SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection. ACS Chemical Neuroscience. 2020;11(9):1200-1203.

Usoskin D, Furlan A, Islam S, Abdo H, Lönnerberg P, Lou D et al. Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nature Neuroscience. 2014;18(1):145-153.

Zylka M, Rice F, Anderson D. Topographically Distinct Epidermal Nociceptive Circuits Revealed Sby Axonal Tracers Targeted to Mrgprd. Neuron. 2005;45(1):17-25.

Hockley J, Taylor T, Callejo G, Wilbrey A, Gutteridge A, Bach K et al. Single-cell RNAseq reveals seven classes of colonic sensory neuron. Gut. 2018;68(4):633-644.

Von Buchholtz L, Lam R, Emrick J, Chesler A, Ryba N. Assigning transcriptomic class in the trigeminal ganglion using multiplex in situ hybridization and machine learning. 2020.

Shiers S, Ray P, Wangzhou A, Tatsui C, Rhines L, Li Y et al. ACE2 expression in human dorsal root ganglion sensory neurons: implications for SARS-CoV-2 virus-induced neurological effects. 2020;.

Dean R, Lue T. Physiology of Penile Erection and Pathophysiology of Erectile Dysfunction. Urologic Clinics of North America. 2005;32(4):379-395.

Vlachopoulos C, Aznaouridis K, Ioakeimidis N, Rokkas K, Vasiliadou C, Alexopoulos N, et al. Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease. Eur Heart J. 2006;27(22):2640–8.

Eaton CB, Liu YL, Mittleman MA, Miner M, Glasser DB & Rimm EB. (2007) A retrospective study of the relationship between biomarkers of atherosclerosis and erectile dysfunction in 988 men. Int J Impot Res 19, 218–225.

Liu P, Blet A, Smyth D, Li H. The Science Underlying COVID-19. Circulation. 2020;142(1):68-78.

Varga Z, Flammer A, Steiger P, Haberecker M, Andermatt R, Zinkernagel A et al. Endothelial cell infection and endotheliitis in COVID-19. The Lancet. 2020;395(10234):1417-1418.

Downloads

Published

2021-06-09

How to Cite

Mahardhika, G. S., Maharani, N., Tedjamartono, T. D., & Ismail, E. (2021). Erectile Dysfunction and COVID-19: a Case Report. Jurnal Profesi Medika : Jurnal Kedokteran Dan Kesehatan, 15(1). https://doi.org/10.33533/jpm.v15i1.2715