Repercussions of COVID-19 pandemic impacts on non-metastatic HER2-negative breast cancer diagnosis and neoadjuvant treatment over patients’ quality of life and mental health/ Repercussões dos impactos da pandemia COVID-19 no diagnóstico e tratamento neoadjuvante de câncer de mama HER2-negativo não metastático sobre a qualidade de vida e saúde mental das pacientes

Authors

  • Glendha de Sousa Kemer Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Ricardo Pasquini Neto
  • João Gabriel Vicentini Karvat
  • Isabela Hodecker da Silveira
  • Maria Júlia Pilau Bornia
  • Mariana Cristina Gomes Morila
  • Maria Cristina Figueroa Magalhães

DOI:

https://doi.org/10.34119/bjhrv5n2-265

Keywords:

breast neoplasms, COVID-19, mental health, anxiety, depression

Abstract

OBJECTIVE: To understand if COVID-19 pandemic impacts on delays in non-metastatic HER2-negative breast cancer diagnosis and in the beginning/development of neoadjuvant chemotherapy, as well as on changes in treatment plan to Paclitaxel intensification doses, impaired patients’ quality of life and mental health. METHODS: This is a cross-sectional study of 67 women diagnosed with non-metastatic HER2-negative breast cancer during the first sixteen months of COVID-19 pandemic and receiving neoadjuvant treatment due to pandemic impossibility of immediate definitive cancer surgery following the neoplasm diagnosis. Sociodemographic, Functional Assessment of Cancer Therapy Scale - General, Beck Anxiety and Depression Inventory were used for outcomes assessment. Inferential analysis was performed by Mann-Whitney, Pearson's chi-squared, and Fisher's exact tests. The adopted significance was 5%. RESULTS: The study revealed that the oncological diagnosis delays caused a worsening of the patients' physical (8 x 21; p = 0.001), functional (13 x 21; p = 0.03) and general (61 x 83; p = 0.004) well-being; retardment in the beginning of neoadjuvant chemotherapy decreased physical well-being (13 x 21; p = 0.01). Changes in treatment plan, to Paclitaxel doses intensification, had a negative effect on functional well-being (20 x 25.5; p = 0.04). COVID-19 pandemic impacts on neoplasm diagnosis and neoadjuvant treatment delays were also associated with psychosocial manifestations, including higher levels of severe anxiety (60% x 14.5%; p = 0.03 and 40% x 14%; p = 0.04) and depression (40% x 3.2%; p = 0.004 and 60% x 5.3%; p = 0.03) respectively. CONCLUSION: The present study shows that COVID-19 pandemic impacts on non-metastatic HER2-negative breast cancer patients’ diagnosis and neoadjuvant chemotherapy impaired patients' quality of life and mental health.

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Published

2022-04-20

How to Cite

KEMER, G. de S.; NETO, R. P.; KARVAT, J. G. V.; SILVEIRA, I. H. da; BORNIA, M. J. P.; MORILA, M. C. G.; MAGALHÃES, M. C. F. Repercussions of COVID-19 pandemic impacts on non-metastatic HER2-negative breast cancer diagnosis and neoadjuvant treatment over patients’ quality of life and mental health/ Repercussões dos impactos da pandemia COVID-19 no diagnóstico e tratamento neoadjuvante de câncer de mama HER2-negativo não metastático sobre a qualidade de vida e saúde mental das pacientes. Brazilian Journal of Health Review, [S. l.], v. 5, n. 2, p. 7002–7019, 2022. DOI: 10.34119/bjhrv5n2-265. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/46807. Acesso em: 29 mar. 2024.

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Original Papers