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Endocrine Abstracts (2021) 73 AEP424 | DOI: 10.1530/endoabs.73.AEP424

ECE2021 Audio Eposter Presentations General Endocrinology (51 abstracts)

The association of Vitamin D deficiency with COVID-19 severity and mortality

Mitra Kazemijahromi 1 , HamidReza Samimagham 2 , Mehdi Hassani Azad 3 , Mohsen Arabi 4 & Dariush Hooshyar 5


1Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandarabbas, Iran; 2Clinical Research Development Center, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran; 3Infectious and Tropical Diseases Research Center, Hormozgan Health Institue, Hormozgan University of Medical Sciences, Bandar Abbas, Iran; 4Department of Internal Medicine and Public Health Research Center, Family Medicine Department, Iran University of Medical Sciences, Tehran, Iran; 5Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


Background and objective

There are few studies showing the association between vitamin D deficiency and COVID-19 severity and mortality. This study designed to investigate the relationship between vitamin D deficiency and the severity and mortality of COVID-19.

Methods

The present cross-sectional study was conducted on 48 COVID-19 patients with positive PCR test results. Patients were divided into three groups according to their serum 25-OH vitamin D3 levels: group 1 < 20 ng/ml, group 2. 20–50 ng/ml, and group 3, ≥ 50 ng/ml. The relationship of the levels of vitamin D3, as well as the history of diabetes, hypertension, Ischemic Heart Disease (IHD), Glomerular Filtration Rate(GFR) ≤ 60 ml/min, LDH ≥ 500 U/l, and Lymphocyte count ≤ 1500 with the severity of the disease and its mortality were investigated.

Results

A significant relationship was observed between vitamin D ≤ 20 ng/ml and the severity of the disease (P < 0.001) and mortality (P = 0.001, adjusted OR = 2.4) in COVID-19 patients. It was also shown that GFR ≤ 60 ml/min (P = 0.02, adjusted OR = 3.6), IHD (P = 0.04, adjusted OR = 2.8), LDH ≥ 500 U/l (P = 0.027, adjusted OR = 1.8) and lymphocyte count ≤ 1500 (P = 0.002, adjusted OR = 2.2) significantly affected the mortality.

Conclusion

The present study showed a significant relationship between vitamin D deficiency and the severity of the disease and mortality in COVID-19 patients. These results suggest the need for appropriate health policies during the COVID-19 pandemic.

Volume 73

European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

European Society of Endocrinology 

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