Altered Vascular Endothelium-Dependent Responsiveness in Frail Elderly Patients Recovering from COVID-19 Pneumonia: Preliminary Evidence
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Overview
2.1.1. Data Collection
2.1.2. Systemic Vascular Function via sPLM
2.1.3. Level of Physical Function
2.2. Data Analysis
3. Results
4. Discussion
Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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COVID-19 Patients (n = 22) | CTRL (n = 22) | p | |
---|---|---|---|
Age, years | 72.6 ± 8.7 | 72.5 ± 8.5 | 0.9694 |
Sex, male% | 72.7 | 68.2 | 0.7436 |
BMI, Kg/m2 | 24.7 ± 3.3 | 24.6 ± 1.8 | 0.9013 |
Barthel index, score | 76.6 ± 25.7 | 98.1 ± 3.7 | 0.0004 |
6-MWT, meters | 195.4 ± 117.1 | 545 ± 135.5 | <0.001 |
SPPB, score | 5.8 ± 3.7 | 10.7 ± 0.6 | <0.001 |
Comorbidities, % | |||
Hypertension | 57 | 56 | 0.9467 |
Diabetes | 19 | 30 | 0.3963 |
Heart failure | 26 | 19 | 0.5782 |
Ischemic Heart Disease | 17 | 10 | 0.4969 |
Pulmonary Chronic Disease | 39 | 28 | 0.4395 |
CIRS1, score | 2.2 ± 0.6 | ||
CIRS2, score | 5.8 ± 3.1 | ||
PaO2, mmHg | 61.2 ± 8.5 | Normal value: >85 mmHg | |
PaCO2, mmHg | 42.3 ± 3.6 | Normal value: 37–43 mmHg | |
pH | 7.43 ±0.01 | Normal value: 7.37–7.44 | |
FEV1, % | 71 ± 23 | Normal value: >80% | |
FVC, % | 63 ± 23 | Normal value: 80–120% | |
FEV1/FVC | 89 ± 10 | Normal value: 80 | |
CRP, mg/dl | 27.13 ± 37.52 | Normal Value: ≤5 mg/L | |
ESR, mm/h | 64.24 ± 32.37 | Normal value: W ≤ 30 mm/h M ≤ 20 mm/h | |
47.33 ± 25.06 | |||
73.45 ± 30.65 | |||
D-dimer, ng/ml | 1043 ± 729 | Normal value: ≤300 ng/mL | |
Clinical History, % | |||
Mechanical ventilation use | 41 | ||
Oxygen | 100 | ||
Embolism | 23 | ||
Pneumothorax | 23 | ||
Drugs, % | |||
Anti-rheumatic | 5 | ||
Cortisone | 30 | ||
Anti-malarial | 35 | ||
Anti-viral | 25 | ||
Anti-platelet | 53 |
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Paneroni, M.; Pasini, E.; Vitacca, M.; Scalvini, S.; Comini, L.; Pedrinolla, A.; Venturelli, M. Altered Vascular Endothelium-Dependent Responsiveness in Frail Elderly Patients Recovering from COVID-19 Pneumonia: Preliminary Evidence. J. Clin. Med. 2021, 10, 2558. https://doi.org/10.3390/jcm10122558
Paneroni M, Pasini E, Vitacca M, Scalvini S, Comini L, Pedrinolla A, Venturelli M. Altered Vascular Endothelium-Dependent Responsiveness in Frail Elderly Patients Recovering from COVID-19 Pneumonia: Preliminary Evidence. Journal of Clinical Medicine. 2021; 10(12):2558. https://doi.org/10.3390/jcm10122558
Chicago/Turabian StylePaneroni, Mara, Evasio Pasini, Michele Vitacca, Simonetta Scalvini, Laura Comini, Anna Pedrinolla, and Massimo Venturelli. 2021. "Altered Vascular Endothelium-Dependent Responsiveness in Frail Elderly Patients Recovering from COVID-19 Pneumonia: Preliminary Evidence" Journal of Clinical Medicine 10, no. 12: 2558. https://doi.org/10.3390/jcm10122558