Elsevier

Revue Neurologique

Volume 179, Issue 6, June 2023, Pages 630-635
Revue Neurologique

Brief Report
Immune-mediated necrotizing myopathy following vaccination with the AstraZeneca (AZD1222) COVID-19 vaccine: A case report and brief review

https://doi.org/10.1016/j.neurol.2022.11.009Get rights and content

Abstract

Immune-Mediated Necrotizing Myopathy (IMNM) after vaccination has been reported previously, however it is rare after COVID-19 vaccination. We report the first case of IMNM two weeks after vaccination with the AstraZeneca (AZD1222) COVID-19 vaccine. There was a probable temporal relationship between the COVID-19 vaccination and the development of IMNM due to lack of known causative factors for IMNM. This may have been due to 1) autoimmunity directly caused by the vaccine, 2) exacerbation of autoimmunity triggered by the vaccine or 3) autoimmune syndrome triggered by the vaccine adjutants. Further studies are needed to assess the underlying mechanisms.

Keywords

Myositis
COVID-19
Vaccines
Rhabdomyolysis
Necrotizing autoimmune myopathy

Cited by (0)

1

BA and MAN have contributed equally to this article.

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