Ki-67 Expression Level in placentas with COVID-19 Infected Women

DOI https://doi.org/10.22270/jddt.v12i1-S.5324

Abstract

Objective:  The SARS-CoV-2 virus, which emerged in December 2019 in Wuhan, China, spread very quickly in a short time and was declared a pandemic by the World Health Organization in March 2020. Physiological and immunological changes during pregnancy cause complications in respiratory tract infections. Complications by COVID-19 lead to a systemic effect that causes maternal and fetal mortality and morbidity. In this study, we aimed to investigate histopathological changes and Ki-67 expression in placentas of women with positive COVID-19 infection.


Study Design: Placentas of 10 samples COVID-19 positive and 10 samples Covid-19 negative pregnant patients who were hospitalized in the Gynecology and Obstetrics Clinic of Dicle University Faculty of Medicine were included in the study. Placental tissues were fixed in 10% formaldehyde (24 hours) and processed for routine paraffin wax tissue staining. Hematoxylin Eosin dye and Ki-67 immunohistochemical staining were performed.


Results:  Decidual cell degeneration, increased numbers of syncytial nodes, dilatation in vessels, degenerated villi were observed in the placentas of COVID-19 positive pregnant women. COVID-19 damage regular histology of placental structures. Ki-67 expression was intensely increased in COVID-19 positive placentas compared to COVID-19 negative placentas.


Conclusion: We suggest that COVID-19 causes some abnormalities in the histology of placentas and cell death, which leads to new cell proliferation.


Keywords: COVID-19, placenta, villi, Ki-67, histopathology

Keywords: COVID19, placenta, villi, Ki-67, histopathology

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Author Biographies

Sevil Kıratlı, Department of Histology and Embryology, Faculty of Medicine, Dicle University, 21010, Diyarbakır, Turkey

Department of Histology and Embryology, Faculty of Medicine, Dicle University, 21010, Diyarbakır, Turkey

Ayfer Aktaş, Department of Histology and Embryology, Faculty of Medicine, Dicle University, 21010, Diyarbakır, Turkey

Department of Histology and Embryology, Faculty of Medicine, Dicle University, 21010, Diyarbakır, Turkey

Fırat Aşır, Department of Histology and Embryology, Faculty of Medicine, Dicle University, 21010, Diyarbakır, Turkey

Department of Histology and Embryology, Faculty of Medicine, Dicle University, 21010, Diyarbakır, Turkey

Işılay Sezen Ermiş, Department of Histology and Embryology, Faculty of Medicine, Dicle University, 21010, Diyarbakır, Turkey

Department of Histology and Embryology, Faculty of Medicine, Dicle University, 21010, Diyarbakır, Turkey

Engin Deveci, Department of Histology and Embryology, Faculty of Medicine, Dicle University, 21010, Diyarbakır, Turkey

Department of Histology and Embryology, Faculty of Medicine, Dicle University, 21010, Diyarbakır, Turkey

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1.
Kıratlı S, Aktaş A, Aşır F, Ermiş IS, Deveci E. Ki-67 Expression Level in placentas with COVID-19 Infected Women. JDDT [Internet]. 15Feb.2022 [cited 17Apr.2024];12(1-S):29-3. Available from: https://jddtonline.info/index.php/jddt/article/view/5324
Issue
Vol 12 No 1-S (2022): Volume 12, Issue 1-S, Jan-Feb 2022
Section
Research
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