Transaminase Level of Severity and Mortality of COVID-19 Patients at RSUD Dr. Saiful Anwar Malang
DOI:
https://doi.org/10.21776/ub.crjim.2022.003.02.3Keywords:
COVID-19, Transminase, albumin, CRPAbstract
Background: Extend of lung injury, inflammation due to SARS COV-2 can also cause liver injury. Liver injury in COVID-19 patients can be caused by the direct effect on the liver, cholangiocyte role, activation of the immune system, drug-induced liver injury, and hypoxic injury. Hepatocyte necrosis could increase the transaminase. Therefore, transaminase increase may reveal the inflammation severity.
Aim: This study aims to know the relationship of transaminase to the severity and mortality of COVID-19 patients.
Method: A retrospective study of 177 COVID-19 patients hospitalized at Saiful Anwar Hospital Malang. The data were taken from the medical record of COVID-19 patients. The level of transaminase was taken on admission. The severity criteria of COVID-19 were taken from the Indonesian COVID-19 Guidelines. Chi-Square Test and Pearson Correlation Test were used as the statistical analysis with a significance of 0.05 (p=0.05) and a confidence interval of 95% (CI=95%).
Results: From the correlation test, the AST had R=0.42 (p < 0.001) for severity and R=0.17 (p < 0.001) for mortality. The ALT had R=0.33 (p < 0.001) of severity and R=0.28 (p < 0.001) of mortality.
Conclusion: There was a significant relationship between AST and ALT in the severity and mortality.
References
Alqahtani S, Schattenberg J. Liver injury in COVID‐19: The current evidence. United European Gastroenterology Journal. 2020;8(5):509-519.
Ahnach M, Zbiri S, Nejjari S, Ousti F, Elkettani C. C-reactive protein as an early predictor of COVID-19 severity. Journal of Medical Biochemistry. 2020;39(4):500-507.
Boregowda U, Aloysius M, Perisetti A, Gajendran M, Bansal P, Goyal H. Serum Activity of Liver Enzymes Is Associated With Higher Mortality in COVID-19: A Systematic Review and Meta-Analysis. Frontiers in Medicine. 2020;7:431.
Brito C, Barros F, Lopes E. Mechanisms and consequences of COVID-19 associated liver injury: What can we affirm?. World Journal of Hepatology. 2020;12(8):413-422.
Cai Q, Huang D, Yu H, Zhu Z, Xia Z, Su Y et al. COVID-19: Abnormal liver function tests. Journal of Hepatology. 2020;73(3):566-574.
Guan W, Ni Z, Hu Y, Liang W, Ou C, He J et al. Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine. 2020;382(18):1708-1720.
Hajifathalian K, Krisko T, Mehta A, Kumar S, Schwartz R, Fortune B et al. Gastrointestinal and Hepatic Manifestations of 2019 Novel Coronavirus Disease in a Large Cohort of Infected Patients From New York: Clinical Implications. Gastroenterology. 2020;159(3):1137-1140.e2.
Huang J, Cheng A, Kumar R, Fang Y, Chen G, Zhu Y et al. Hypoalbuminemia predicts the outcome of COVID‐19 independent of age and co‐morbidity. Journal of Medical Virology. 2020;92(10):2152-2158.
Jiang S, Wang R, Li L, Hong D, Ru R, Rao Y et al. Liver Injury in Critically Ill and Non-critically Ill COVID-19 Patients: A Multicenter, Retrospective, Observational Study. Frontiers in Medicine. 2020;7.
Jothimani D, Venugopal R, Abedin M, Kaliamoorthy I, Rela M. COVID-19 and the liver. Journal of Hepatology. 2020;73(5):1231-1240.
Kumar A, Kumar P, Dungdung A, Kumar Gupta A, Anurag A, Kumar A. Pattern of liver function and clinical profile in COVID-19: A cross-sectional study of 91 patients. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020;14(6):1951-1954.
Kumar P, Sharma M, Kulkarni A, Rao P. Pathogenesis of Liver Injury in Coronavirus Disease 2019. Journal of Clinical and Experimental Hepatology. 2020;10(6):641-642.
Lei F, Liu Y, Zhou F, Qin J, Zhang P, Zhu L et al. Longitudinal Association Between Markers of Liver Injury and Mortality in COVID‐19 in China. Hepatology. 2020;72(2):389-398.
Papadopoulos N. COVID-19 and liver injury: where do we stand?. Annals of Gastroenterology. 2020;
PDPI, PERKI, PAPDI, PERDATIN, IDAI., 2020. Pedoman Tatalaksana COVID-19. Edisi 2. Jakarta, Agustus 2020.
Paliogiannis P, Mangoni A, Cangemi M, Fois A, Carru C, Zinellu A. Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis. Clinical and Experimental Medicine. 2021;21(3):343-354.
Putri R. Indonesia dalam Menghadapi Pandemi Covid-19. Jurnal Ilmiah Universitas Batanghari Jambi. 2020;20(2):705.
Sharifpour M, Rangaraju S, Liu M, Alabyad D, Nahab F, Creel-Bulos C et al. C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19. PLOS ONE. 2020;15(11):e0242400.
Wiersinga W, Rhodes A, Cheng A, Peacock S, Prescott H. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19). JAMA. 2020;324(8):782.
Yang R, Zheng R, Fan J. Etiology and management of liver injury in patients with COVID-19. World Journal of Gastroenterology. 2020;26(32):4753-4762.
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