Plausible role of Arq Ajīb in combating COVID-19: A multi-faceted review

Abstract

The current pandemic caused by SARS-CoV-2 has led to a massive change in every aspect of our lives. It has grossly affected the healthcare system, business and world trade, disruption of movement and supply of essential goods and has crippled the global economy. Although few vaccines have been approved for the control of disease, targeted therapy options for this virulent disease still remain limited and elusive. Exhaustive search for potent therapeutic candidate is in progress, for which herbal armory are also being explored. Medicinal plants and their products play a vital role in alleviating various diseases and have been reported to exhibit a wide range of biological activities. Plant-based drugs with antiviral, anti-inflammatory and immunomodulotry activities were hypothetically considered as potential drugs to prevent and mitigate the prevailing situation caused by SARS-CoV-2. Arq Ajīb ‘a Unani formulation’ presents compelling approach in treating numerous diseases. The ingredients of Arq Ajīb and their phytocompounds have been reported for wide-ranging pharmaco-biological activities including antiviral, anti-inflammatory, immunomodulotry, anti-allergic, antitussive and bronchodilatory activities. Scientific data available on the formulation ingredients and their phytocompounds indicates that the formulation may have a significant role in augmenting the immune status of individual, protecting them from infection and providing symptomatic relief to patients affected with COVID-19. Hence, it may be considered as a potential drug for the development of novel therapeutic candidate for SARS-CoV-2 infection. This multi-faceted review highlights the therapeutic significance and pharmacological actions of Arq Ajīb and its ingredients to demonstrate the plausible role of the formulation in combating COVID-19.


Keywords: Arq Ajīb, COVID-19, Pudina, Ajwain, Camphor, Unani formulation

Keywords: Arq Ajīb, COVID-19, Pudina, Ajwain, Camphor, Unani formulation

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Author Biographies

Noman Anwar, Regional Research Institute of Unani Medicine, Chennai, Tamil Nadu, India.

Regional Research Institute of Unani Medicine, Chennai, Tamil Nadu, India.

N. Zaheer Ahmed, Regional Research Institute of Unani Medicine, Chennai

Regional Research Institute of Unani Medicine, Chennai, Tamil Nadu, India.

Shehnaz Begum, Regional Research Institute of Unani Medicine, Chennai

Regional Research Institute of Unani Medicine, Chennai, Tamil Nadu, India.

References

1. Mofijur M, Fattah IMR, Alam MA, et al. Impact of COVID-19 on the social, economic, environmental and energy domains: Lessons learnt from a global pandemic. Sustain Prod Consum. 2021; 26:343-359. https://doi:10.1016/j.spc.2020.10.016
2. World Health Organization. Coronavirus disease (COVID-19) pandemic 2021. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019
3. World Health Organization. World Health Emergency Dashboard: WHO (COVID-19) Homepage 2021. Available at: https://covid19.who.int/region/searo/country/in
4. Zheng J. SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat. Int J Biol Sci 2020; 16(10):1678–1685. https://doi.org/10.7150/ijbs.45053
5. Nikhat S, Fazil M. Overview of Covid-19; its prevention and management in the light of Unani medicine. Sci Total Environ 2020; 728:138859. https://doi.org/10.1016/j.scitotenv.2020.138859
6. Ismail EM, Shantier SW, Mohammed MS, Musa HH, Osman W, Mothana RA. Quinoline and Quinazoline Alkaloids against COVID-19: An In Silico Multitarget Approach. Journal of Chemistry 2021; ID 3613268: https://doi.org/10.1155/2021/3613268.
7. Tahir Ul Qamar M, Alqahtani SM, Alamri MA, Chen LL. Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants. J Pharm Anal. 2020; 10(4):313-319. doi:10.1016/j.jpha.2020.03.009
8. Dias DA, Urban S, Roessner U. A historical overview of natural products in drug discovery. Metabolites. 2012; 2(2):303-336. Published 2012 Apr 16. doi:10.3390/metabo2020303
9. Mukherjee PK. Antiviral Evaluation of Herbal Drugs. Quality Control and Evaluation of Herbal Drugs 2019: 599–628. https://doi.org/10.1016/B978-0-12-813374-3.00016-8
10. Anonymous. The Unani Pharmacopoeia of India, Part 2, Volume 1, 1st ed. New Delhi: Central Council for Research in Unani Medicine, 2009: 5-6.
11. Khan A. Qarabadeen Azam -o- Akmal (Urdu translation). New Delhi: Central Council for Research in Unani Medicine, 2005: 405.
12. Anonymous. Qarabadeen Jadeed. New Delhi: Central Council for Research in Unani Medicine, 2005: 152-3.
13. Khan MA, Khan NA, Qasmi IA, Ahmad G, Zafar S. Protective effect of Arque-Ajeeb on acute experimental diarrhoea in rats. BMC Complement Altern Med 2004; 4:8. doi:10.1186/1472-6882-4-8.
14. Kabiruddin M. Al-Qarabadeen. New delhi: Central Council for Research in Unani Medicine, 2006: 848.
15. Saleem MN and Idris M. Podina (Mentha arvensis): Transformation from food additive to multifunctional medicine. ARC Journal of Pharmaceutical Science, 2016; 2 (2):6-15. https://doi.org/10.20431/2455-1538.0202002
16. Thawkar BS, Jawarkar AG, Kalamkar PV, Pawar KP, Kale MK. Phytochemical and pharmacological review of Mentha arvensis. International Journal of Green Pharmacy, 2016; 10(2):71-76.
17. Ghani N. Khazain al-Avia. New Delhi: Idara Kitab al-Shifa, 2011: 478-80, 202-3, 999-1004.
18. Kabiruddin M. Makhzanul Mufradat. New Delhi: Idara Kitab al-Shifa, 2007: 140.
19. Baitar I. Kitab al-Jame li Mufradat al-Advia wa al-Aghziya, Volume 1V. New Delhi: Central Council for Research in Unani Medicine, 2003: 397-9, 379-81, 115-117.
20. Ali AM, Mackeen MM, El-Sharkawy SH, Hamid JA, Ismail NH, Ahmad FB, Lajis NH. Antiviral and Cytotoxic Activities of Some Plants Used in Malaysian Indigenous Medicine. Pertanika J Trop Agric Sci, 1996; 19(2/3):129-136.
21. Biswas NN, Saha S, Ali MK. Antioxidant, antimicrobial, cytotoxic and analgesic activities of ethanolic extract of Mentha arvensis L. Asian Pacific Journal of Tropical Biomedicine, 2014; 4 (10): 792-797. https://doi.org/10.12980/APJTB.4.2014C1298
22. Imai H, Osawa K, Yasuda H, Hamashima H, Arai T, Sasatsu M. Inhibition by the essential oils of peppermint and spearmint of the growth of pathogenic bacteria. Microbios, 2001; 106 (Suppl 1):31-9.
23. Wannissorn B, Jarikasem S, Siriwangchai T, Thubthimthed S. Antibacterial properties of essential oils from Thai medicinal plants. Fitoterapia, 2005; 76:233-6. https://doi.org/10.1016/j.fitote.2004.12.009
24. Coutinho HD, Costa JG, Lima EO, Falcão-Silva VS, Siqueira-Júnior JP. Potentiating effect of Mentha arvensis and chlorpromazine in the resistance to aminoglycosides of methicillin-resistant Staphylococcus aureus. In vivo (Athens, Greece), 2009; 23(2):287–289.
25. Malik F, Hussain S, Sadiq A, Parveen G, Wajid A, Shafat S, et al. Phytochemical analysis, anti-allergic and anti-inflammatory activity of Mentha arvensis in animals. African Journal of Pharmacy and Pharmacology, 2012; 6 (9):613-619. https://doi.org/10.5897/AJPP11.702
26. Chandan K, Vishwakarma S, Jeba RC, Khushbu S. Anti Cancer Activity of Mentha arvensis. IAJPR, 2014; 4(5):2465-2469.
27. Sharma V, Hussain S, Gupta M, Saxena AK. In vitro Anticancer Activity of Extracts of Mentha Spp. against Human Cancer Cells. IJBB, 2014; 51(5):416-419.
28. Jagetia, G., Baliga, M. Influence of the leaf extract of Mentha arvensis Linn. (Mint) on the survival of mice exposed to different doses of Gamma Radiation. Strahlenther Onkol, 2002; 178:91–98. https://doi.org/10.1007/s00066-002-0841-y
29. Baliga MS, Rao S. Radioprotective potential of mint: a brief review. J Cancer Res Ther, 2010; 6(3):255-262. doi:10.4103/0973-1482.73336
30. Khan S, Shameem I, Sahibole S, Siddiqui A. Trachyspermum ammi: ancient Unani medicine for modern cure, a review of potential therapeutic applications. World Journal of Pharmaceutical Research, 2016; 5 (12):169-178.
31. Bairwa R, Sodha RS, Rajawat BS. Trachyspermum ammi. Pharmacogn Rev, 2012; 6 (11): 56-60. https://doi.org/10.4103/0973-7847.95871
32. Roy S, Chaurvedi P, Chowdhary A. Evaluation of antiviral activity of essential oil of Trachyspermum Ammi against Japanese encephalitis virus. Pharmacognosy research, 2015; 7(3):263–267. https://doi.org/10.4103/0974-8490.157977
33. Hussein G, Miyashiro H, Nakamura N, Hattori M, Kakiuchi N, Shimotohno K. Inhibitory effects of sudanese medicinal plant extracts on hepatitis C virus (HCV) protease. Phytotherapy research, 2000; 14(7): 510–516. https://doi.org/10.1002/1099-1573(200011)14:7<510::aid-ptr646>3.0.co;2-b
34. Ardestani MM, Aliahmadi A, Toliat T, Dalimi A, Momeni Z, Rahimi R. Evaluation of antimicrobial activity of Trachyspermum ammi (L.) Sprague essential oil and its active constituents, Thymol, against veginal pathogens. Traditional and Integrative Medicine, 2020; 5 (2):49-58.
35. Moein MR, Zomorodian K, Pakshir K, Yavari F, Motamedi M, Zarshenas MM. Trachyspermum ammi (L.) sprague: chemical composition of essential oil and antimicrobial activities of respective fractions. Journal of evidence-based complementary & alternative medicine, 2015; 20(1):50–56. https://doi.org/10.1177/2156587214553302
36. Soni R, Sharma G, Jasuja ND. Essential Oil Yield Pattern and Antibacterial and Insecticidal Activities of Trachyspermum ammi and Myristica fragrans. Scientifica, 2016. ID 1428194 https://doi.org/10.1155/2016/1428194.
37. Anilakumar KR, Saritha V, Khanum F, Bawa AS. Ameliorative effect of ajwain extract on hexachlorocyclohexane-induced lipid peroxidation in rat liver. Food and chemical toxicology, 2009; 47(2):279–282. https://doi.org/10.1016/j.fct.2008.09.061
38. Singh A, Ahmad A. Antioxidant Activity of Essential Oil Extracted by SC-CO₂ from Seeds of Trachyspermum ammi. Medicines (Basel, Switzerland), 2017; 4(3): 53. https://doi.org/10.3390/medicines4030053
39. Ranjbaran A, Kavoosi G, Mojallal-Tabatabaei Z, Ardestani SK. The antioxidant activity of Trachyspermum ammi essential oil and thymol in murine macrophages. Biocatalysis and Agricultural Biotechnology, 2019; 20:101220. https://doi.org/10.1016/j.bcab.2019.101220.
40. Korani M, Jamshidi M. The Effect of Aqueous Extract of Trachyspermum ammi Seeds and Ibuprofen on Inflammatory Gene Expression in the Cartilage Tissue of Rats with Collagen-Induced Arthritis. Journal of inflammation research, 2020; 13:133–139. https://doi.org/10.2147/JIR.S236242
41. Khan MR, Jamal MA, Zeenat F. Therapeutic potential of Cinnamomum camphora (Kafoor) in skin disorders: a review. World Journal of Pharmaceutical and Life Science, 2019; 5 (3): 108-111.
42. Singh R, Jawaid T. Cinnamomum camphora (Kapoor): Review. Pharmacognosy Journal, 2012; 4(28): doi.10.5530/pj.2012.28.1
43. Chen W, Vermaak I, Viljoen A. Camphor-A fumigant during the black death and a coveted fragrant wood in ancient Egypt and Babylon – A review. Molecules 2013; 18:5434-5454. https://doi.org/10.3390/molecules18055434
44. Wang W, Li D, Huang X, Yang H, Qiu Z, Zou L, et al. Study on Antibacterial and Quorum-Sensing Inhibition Activities of Cinnamomum camphora Leaf Essential Oil. Molecules (Basel, Switzerland), 2019; 24(20):3792. https://doi.org/10.3390/molecules24203792.
45. Guo S, Geng Z, Zhang W, Liang J, Wang C, Deng Z, et al. The Chemical Composition of Essential Oils from Cinnamomum camphora and Their Insecticidal Activity against the Stored Product Pests. International journal of molecular sciences, 2016; 17(11):1836. https://doi.org/10.3390/ijms17111836
46. Laude EA, Morice AH, Grattan TJ. The antitussive effects of menthol, camphor and cineole in conscious guinea-pigs. Pulmonary pharmacology, 1994; 7(3):179–184. https://doi.org/10.1006/pulp.1994.1021
47. Kumar N, Nepali K, Sapra S, Bijjem KR, Kumar R, Suri OP, Dhar KL. Effect of nitrogen insertion on the antitussive properties of menthol and camphor. Med Chem Res, 2012; 21:531-537. https://doi.org/10.1007/s00044-011-9560-1
48. Lee HJ, Hyun EA, Yoon WJ, Kim BH, Rhee MH, Kang HK, et al. In vitro anti-inflammatory and anti-oxidative effects of Cinnamomum camphora extracts. Journal of ethnopharmacology, 2006; 103(2):208–216. https://doi.org/10.1016/j.jep.2005.08.009
49. Tanabe H, Fukutomi R, Yasui K, Kaneko A, Imai S, Nakayama T, et al. Identification of Dimethylmatairesinol as an Immunoglobulin E-suppressing component of the leaves of Cinnamomum camphora. Journal of Health Science, 2011; 57:184-187. https://doi.org/10.1248/jhs.57.184
50. Nugraha RV, Ridwansyah H, Ghozali M, Khairani AF, Atik N. Traditional herbal medicine candidates as complementary treatments for COVID-19: A review of their mechanisms, pros and cons", Evidence-Based Complementary and Alternative Medicine, 2020: Article ID 2560645. https://doi.org/10.1155/2020/2560645
51. Astani A, Reichling J, Schnitzler P. Comparative study on the antiviral activity of selected monoterpenes derived from essential oils. Phytother Res. 2010; 24 (5):673-679. doi:10.1002/ptr.2955.
52. Anwar N, Ahmed NZ, Fathima AF, Begum S, Khan AA. Emergence of antimicrobial resistance and magnitude of Unani medicine - scope and challenges [published online ahead of print, 2021 Jan 29]. J Complement Integr Med. 2021; 10.1515/jcim-2020-0092. doi:10.1515/jcim-2020-0092
53. Zarubaev VV, Garshinina AV, Tretiak TS, Fedorova VA, Shtro AA, Sokolova AS, et al. Broad range of inhibiting action of novel camphor-based compound with anti-hemagglutinin activity against influenza viruses in vitro and in vivo. Antiviral Res. 2015 Aug; 120:126-33. doi: 10.1016/j.antiviral.2015.06.004.
54. Taylor DJ, Hamid SM, Andres AM, Saadaeijahromi H, Piplani H, Germano JF, et al. Antiviral Effects of Menthol on Coxsackievirus B. Viruses. 2020 Mar 28; 12(4):373. doi: 10.3390/v12040373. PMID: 32231022; PMCID: PMC7232514.
55. Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, et al. Quercetin, Inflammation and Immunity. Nutrients. 2016; 8(3):167. doi: 10.3390/nu8030167.
56. Wu W, Li R, Li X, He J, Jiang S, Liu S, et al. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses 2015; 8(1):6. doi: 10.3390/v8010006.
57. Pandit M, Latha N. In silico studies reveal potential antiviral activity of phytochemicals from medicinal plants for the treatment of COVID-19 infection. Research Squre 2020; https://doi.org/10.21203/rs.3.rs-22687/v1
58. Kulyar MF, Li R, Mehmood K, Waqas M, Li K, Li J. Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic. Phytomedicine. 2021 May; 85:153277. doi: 10.1016/j.phymed.2020.153277. Epub 2020 Jul 10. PMID: 32773257; PMCID: PMC7347483.
59. Chen J, Tang C, Zhou Y, Zhang R, Ye S, Zhao Z, Lin L, Yang D. Anti-Inflammatory Property of the Essential Oil from Cinnamomum camphora (Linn.) Presl Leaves and the Evaluation of Its Underlying Mechanism by Using Metabolomics Analysis. Molecules. 2020 Oct 19; 25(20):4796. doi: 10.3390/molecules25204796. PMID: 33086631; PMCID: PMC7587563.
60. Zaia MG, Cagnazzo TD, Feitosa KA, Soares EG, Faccioli LH, Allegretti SM, et al. Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection. Front Pharmacol. 2016 Jun 17; 7:170. doi: 10.3389/fphar.2016.00170. PMID: 27378927; PMCID: PMC4911957.
61. Wang HW, Liu SC, Chao PZ, Lee FP. Menthol inhibiting parasympathetic function of tracheal smooth muscle. Int J Med Sci. 2016 Nov 17; 13(12):923-928. doi: 10.7150/ijms.17042. PMID: 27994497; PMCID: PMC5165685.
62. Plevkova J, Kollarik M, Poliacek I, Brozmanova M, Surdenikova L, Tatar M, Mori N, Canning BJ. The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol. J Appl Physiol (1985). 2013 Jul 15; 115(2):268-74. doi: 10.1152/japplphysiol.01144.2012. Epub 2013 May 2. PMID: 23640596; PMCID: PMC3727002.
63. Wright CE, Laude EA, Grattan TJ, Morice AH. Capsaicin and neurokinin A-induced bronchoconstriction in the anaesthetised guinea-pig: evidence for a direct action of menthol on isolated bronchial smooth muscle. Br J Pharmacol. 1997 Aug; 121(8):1645-50. doi: 10.1038/sj.bjp.0701319. PMID: 9283698; PMCID: PMC1564874.
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Anwar N, Ahmed NZ, Begum S. Plausible role of Arq Ajīb in combating COVID-19: A multi-faceted review. JDDT [Internet]. 15Jul.2021 [cited 29Mar.2024];11(4):141-8. Available from: https://jddtonline.info/index.php/jddt/article/view/4947