Coronavirus disease 2019 (COVID-19): Immunological approaches and emerging pharmacologic treatments

https://doi.org/10.1016/j.intimp.2020.106885Get rights and content

Highlights

  • CP therapy might be a confident strategy choice for COVID-19 saving.

  • Tocilizumab and Anakinra have shown some benefits in patients with COVID-19.

  • Recent findings show that the HQC has no beneficial effects on COVID-19 patients.

  • hrsACE2, Ivermectin, and EIDD-2801 have exhibited an inhibitory effect against SARS-CoV-2.

  • Recent data show that the only remdesivir has a limited benefit in patients with COVID-19.

Abstract

The SARS-CoV-2 virus is an etiological agent of pandemic COVID-19, which spreads rapidly worldwide. No proven effective therapies currently exist for this virus, and efforts to develop antiviral strategies for the treatment of COVID-19 are underway. The rapidly increasing understanding of SARS-CoV-2 virology provides a notable number of possible immunological procedures and drug targets. However, gaps remain in our understanding of the pathogenesis of COVID-19. In this review, we describe the latest information in the context of immunological approaches and emerging current antiviral strategies for COVID-19 treatment.

Keywords

SARS-CoV-2
COVID-19
Drug targets
Antiviral strategies
Immunological approaches

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