MMSL 2021, 90(4):198-207 | DOI: 10.31482/mmsl.2021.020

CAN BAICALEIN BECOME A NEW DRUG FOR COVID-19?Review article

Jiří Patočka ORCID...1,2*, Zdeňka Navrátilová ORCID...3, Kamil Kuča ORCID...2,4, Patrik Olekąák ORCID...4, Uday Kumar Killi ORCID...5
1 Institute of Radiology, Toxicology and Civil Protection, Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic
2 Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic
3 Department of Botany, Faculty of Science, Charles University in Prague, Czech Republic
4 Department of Chemistry, Faculty of Science, University of Hradec Králové, Hradec Králové, Czech Republic
5 Institute of Plant Molecular Biology, Biology Centre of the Academy of Sciences, Ceské Budejovice, Czech Republic

The ongoing coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global health crisis. Flavon baicalein, a major bioactive molecule of Scutellaria baicalensis, inhibits the replication of SARS-CoV-2 which causes severe acute respiratory syndrome in humans. Animal experiments show that baicalein has the character of a broad-spectrum coronavirus drug. It is non-toxic and can inhibit SARS-CoV-2-induced damage. Baicalein may therefore be a promising therapeutic drug for the treatment of COVID-19.

Keywords: Baicalein and baicalin; Scutellaria baicalensis; antiviral activity; SARS-CoV-2; COVID-19

Received: February 26, 2021; Revised: May 18, 2021; Accepted: May 18, 2021; Prepublished online: May 27, 2021; Published: December 3, 2021  Show citation

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Patočka, J., Navrátilová, Z., Kuča, K., Olekąák, P., & Kumar Killi, U. (2021). CAN BAICALEIN BECOME A NEW DRUG FOR COVID-19? MMSL, 90(4), 198-207. doi: 10.31482/mmsl.2021.020
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