No specific treatment against SARS-CoV-2 is available after 6 months of COVID-19 worldwide outbreak.
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Antivirals could decrease the viral load and reduce direct and indirect damages of SARSCoV-2 infection.
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Ritonavir-bosted lopinavir is effective against SARS-CoV-2 in vitro.
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Sequential virological and pharmacological monitoring helped to understand the efficacy of ritonavir-boosted lopinavir in a SARS-CoV-2 infected patient.
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Ritonavir-boosted lopinavir could be proposed as early treatment for SARS-CoV-2 infection.