Short communicationThe ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway
Section snippets
Short communication
The pandemic of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (2019-nCoV or SARS-CoV-2) infection has become a Public Health Emergency of International Concern (PHEIC) with more than 6 million cases and 376,320 deaths as of June 2, 2020 (WHO, 2020, https://covid19.who.int). SARS-CoV-2 infection causes disorder of natural and adaptive immunity, leading to tissue damage and systemic inflammation, which is the main reason for death of COVID-19 patients (Huang et al., 2020
CRediT authorship contribution statement
Jin-Yan Li: Conceptualization, Methodology, Formal analysis, Investigation, Writing - original draft, Writing - review & editing. Ce-Heng Liao: Methodology, Formal analysis, Investigation. Qiong Wang: Formal analysis, Investigation. Yong-Jun Tan: Resources. Rui Luo: Resources. Ye Qiu: Writing - review & editing, Supervision, Funding acquisition. Xing-Yi Ge: Conceptualization, Writing - review & editing, Supervision, Funding acquisition.
Declaration of Competing Interest
The authors declare that they have no conflict of interest.
Acknowledgements
This work was jointly funded by National Natural Science Foundation of China (grant number 32041001 and 81902070), the Provincial Natural Science Foundation of Hunan Province (grant number 2019JJ20004, 2019JJ50035, and 2020SK3001).
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