Chronic-periodontitis: could it be a connived-culprit of COVID-19?

Authors

  • Nirupa Elisetti Department of Periodontics and Implantology, Nirupa's DENTAL ZONE, Hyderabad, Telangana, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20212621

Keywords:

Angiotensin converting enzyme receptor, Corona virus, Cytokines, Periodontitis, Severe acute respiratory syndrome coronavirus 2

Abstract

Periodontitis is a multi-factorial disease resulting in the disruption of the attachment apparatus. COVID-19 has been alarming to many nations despite consistent efforts. Research has been continuously going on to curb the spread of the disease by gaining knowledge on the insights of the pathology of the disease. The current exploratory research establishes a correlation between periodontitis and COVID-19 and the impact of periodontal health in COVID affected patients. A search was performed using three data bases, PubMed, Scopus and Google Scholar published from 2019 to 2020. The keywords used for the search were COVID-19, and pathogenesis of periodontitis. The results of the search resulted in many reviews, original research, systematic reviews, case reports, etc. The critical selection of the articles especially systematic reviews was given utmost importance. Much less research has been done on the correlation of periodontitis to COVID-19. On the basis of search using the above mentioned keywords, a total of 26 articles were selected out of which only 21 articles were considered for the present exploratory review. The present review provides an insight into the pathogenic aspects of both periodontitis and COVID-19 and helps in establishing an ally which has been minimally explored to date. The pathogenesis of COVID shows a close similarity to periodontitis and henceforth a possible connection of the severity of COVID in patients suffering with chronic periodontitis. Periodontitis presents itself as a risk factor for many systemic diseases, and nevertheless, it has shown a possible similarity in the pathophysiology of COVID-19.

References

Loe H. Periodontal disease: The sixth complication of diabetes mellitus. Diabetes Care. 1993;16:329-34.

Genco R. Periodontal disease and cardiovacular diseases, epidemiology and possible mechanisms. JADA. 2002;133.

Scannapieco FA. Role of oral bacteria in respiratory infection. J Periodontol. 1999;70:793-802.

Hu B, Huang S, Yin L. The cytokine storm and COVID-19. J Med Virol. 2020;10.

Wu D, Yang XO. T H17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib. J Microbiol Immunol Infect. 2020;53:368-70.

Graves D. Cytokines that promote periodontal tissue destruction. J Periodontol. 2008;79:1585-91.

White PC, Chicca IJ, Cooper PR, Milward MR, Chapple ILC. Neutrophil extracellular traps in periodontitis: a web of intrigue. J Dent Res. 2016;95:26-34.

Novel Coronavirus (2019-nCoV) Situation Report – 22. Available at: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200211-sitrep-22-ncov.pdf?sfvrsn=fb6d49b1_2. Accessed on 31 October 2020.

Lu R, Zhao X, Li J. Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395:565-74.

Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020;109:102433.

Wrapp D, Wang N, Corbett KS. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020;367:1260-3.

Girija ASS, Shankar EM, Larsson M. Could SARS-CoV-2-Induced Hyperinflammation Magnify the Severity of Coronavirus Disease (CoViD-19) Leading to Acute Respiratory Distress Syndrome? Front Immunol. 2020;11:1206.

Tang Y, Liu J, Zhang D, Xu Z, Ji J, Wen C. Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies. Front. Immunol. 2020;11:1708.

Xu Z, Shi L, Wang Y. Pathological finding of COVID-19 associated with acute respiratory distress syndrome. Lancet. 2020;8:420-2.

Gu J, Gong E, Zhang B. Multiple organ infection and the pathogenesis of SARS. J Exp Med. 2005;202:415-24.

Assuma R, Oates T, Cochran D, Amar S, Graves DT. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J Immunol. 1998;160:403-9.

Baker PJ, Dixon M, Evans RT, Dufour L, Johnson E, Roopenian DC. CD4 (+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect Immun. 1999;67:2804-9.

Meng L, Hua F, Bian Z. Coronavirus disease 2019 (COVID-19): emerging and future challenges for dental and oral medicine. J Dent Res. 2020;99:481-7.

Pascolo L, Zupin L, Melato M, Tricarico PM, Crovella S. TMPRSS2 and ACE2 Coexpression in SARS-CoV-2 Salivary Glands Infection. J Dent Res. 2020;99:1120-1.

Xu J, Li Y, Gan F, Du Y, Yao Y. Salivary glands: potential reservoirs for COVID-19 asymptomatic infection. J Dent Res. 2020;99:989.

Pizzo G, Guiglia R, Lo Russo L, Campisi G. Dentistry and internal medicine: from the focal infection theory to the periodontal medicine concept. Eur J Intern Med. 2010;21:496-502.

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Published

2021-06-25

How to Cite

Elisetti, N. (2021). Chronic-periodontitis: could it be a connived-culprit of COVID-19?. International Journal Of Community Medicine And Public Health, 8(7), 3589–3592. https://doi.org/10.18203/2394-6040.ijcmph20212621

Issue

Section

Short Communication