SARS-CoV-2 receptor binding domain (RBD) designs for homogeneous monomeric antigen preparations
1 Pages Posted: 14 Feb 2023
Date Written: 2022
Abstract
The SARS-CoV-2 spike ( protein RBD is a prime target of virus neutralizing antibodies and thus, is a key antigen in vaccine development and immunosurveillance The tendency of the widely used RBD fragment (spike amino acids 319 541 to form dimers has already been noticed at a very early stage of its structural and functional characterization after production in various expression systems, but its impact on protein stability remained unknown.
Note: This conference abstract was presented at the 16th Vaccine Conference organized by the journal Vaccine. This abstract has not been screened by SSRN for potential for public harm and should not be used to inform any clinical decision making. No competing interests or funding statements have been declared.
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