SARS-CoV-2 receptor binding domain (RBD) designs for homogeneous monomeric antigen preparations

1 Pages Posted: 14 Feb 2023

See all articles by Miriam Klausberger

Miriam Klausberger

University of Natural Resources and Life Science of Vienna

Nikolaus Kienzl

University of Natural Resources and Life Science of Vienna

Gerhard Stadlmayr

University of Natural Resources and Life Science of Vienna

Lukas Mach

University of Natural Resources and Life Science of Vienna

Gordana Wozniak Knopp

University of Natural Resources and Life Science of Vienna

Date Written: 2022

Abstract

The SARS-CoV-2 spike ( protein RBD is a prime target of virus neutralizing antibodies and thus, is a key antigen in vaccine development and immunosurveillance The tendency of the widely used RBD fragment (spike amino acids 319 541 to form dimers has already been noticed at a very early stage of its structural and functional characterization after production in various expression systems, but its impact on protein stability remained unknown.

Note: This conference abstract was presented at the 16th Vaccine Conference organized by the journal Vaccine. This abstract has not been screened by SSRN for potential for public harm and should not be used to inform any clinical decision making. No competing interests or funding statements have been declared.

Suggested Citation

Klausberger, Miriam and Kienzl, Nikolaus and Stadlmayr, Gerhard and Mach, Lukas and Knopp, Gordana Wozniak, SARS-CoV-2 receptor binding domain (RBD) designs for homogeneous monomeric antigen preparations (2022). 16TH VACCINE CONGRESS, Available at SSRN: https://ssrn.com/abstract=4358880 or http://dx.doi.org/10.2139/ssrn.4358880

Miriam Klausberger (Contact Author)

University of Natural Resources and Life Science of Vienna ( email )

Vienna
Austria

Nikolaus Kienzl

University of Natural Resources and Life Science of Vienna

Vienna
Austria

Gerhard Stadlmayr

University of Natural Resources and Life Science of Vienna

Vienna
Austria

Lukas Mach

University of Natural Resources and Life Science of Vienna

Vienna
Austria

Gordana Wozniak Knopp

University of Natural Resources and Life Science of Vienna

Vienna
Austria

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