Generic placeholder image

Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Review Article

Coronavirus Disease 2019: Virology and Drug Targets

Author(s): Praveen Thaggikuppe Krishnamurthy*

Volume 21, Issue 8, 2021

Published on: 09 December, 2020

Article ID: e160921188929 Pages: 8

DOI: 10.2174/1871526520666201209145302

Price: $65

Abstract

The Coronavirus Disease 2019, a pandemic caused by novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is seriously affecting global health and the economy. As the vaccine development takes time, the current research is focused on repurposing FDA approved drugs against the viral target proteins. This review discusses the current understanding of SARSCoV- 2 virology, its target structural proteins (S-glycoprotein), non-structural proteins (3-chymotrypsin- like protease, papain-like protease, RNA-dependent RNA polymerase, and helicase) and accessory proteins, drug discovery strategies (drug repurposing, artificial intelligence, and high- -throughput screening), and the current status of antiviral drug development.

Keywords: SARS-CoV-2, CoVID-19, drug targets, virology, WHO, S-glycoprotein.

Graphical Abstract

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy