Clinical analysis of relationship between clot formation in COVID-19 patients and presence of antiphosppholipid
Antibodies by case control study In Holly Karbala City
Keywords:
COVID-19, aPLs, autoimmunityAbstract
Objective. One of the hallmarks seen in severely sick individuals with coronavirus illness is coagulopathy (COVID-19). Antiphospholipid antibodies (aPLs) play a role in coagulopathy, although their significance in COVID-19 is unknown. The purpose of this study was to identify the prevalence and features of aPLs in COVID-19 patients. Method :80 patients were admite to the hospital .40 of them were positive inRT- PCR test for COVID-19 infection and the other 40 were healthy control. Both groups were tested for the incidence of Anti-phospholipid-Igm Ab. Result: all patient showed higher levels of antiphospholipids antibodies (0.965±2.07) then in control group (0.023±0.0005) with p-value (0.004). Conclusion. Antiphospholipid antibodies were frequently appeared in COVID-19-infected patients. COVID-19 infection might trigger the development of a condition of autoimmunity resamble the antiphospholipid syndrome (APS), forming what called a "COVID-19–induced APS-like syndrome". tasting reports appears medium to high levels of aPLs that would disappear within a few weeks in infected patients. The identification of aPLs would gave appropriate clew for COVID-19 infection.
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