Heliyon
Volume 6, Issue 12, December 2020, e05635
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Research article
Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis

https://doi.org/10.1016/j.heliyon.2020.e05635Get rights and content
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Abstract

Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, patients with long-term SARS-CoV-2 infection also exhibited a significant blockade of T-cells proliferation.

Keywords

Inflammation
Infectious disease
Pathology
Virology
Immunology
COVID19
Sepsis
T cell proliferation
Immune checkpoints
PD-L1/PD-1
T cell exhaustion

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Equal contribution.