Short communication
De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019

https://doi.org/10.1016/j.jiph.2022.10.025Get rights and content
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Abstract

The immune response is a key player in the course of SARS-CoV-2 infection, and is often seriously dysfunctional in severe Coronavirus Disease 2019. The hyperinflammatory status has been described to be accompanied by the appearance of autoantibodies. In a lethal COVID-19 infection, we observed the emergence of a de novo natural alloantibody which targeted the M antigen from the MNS blood group on red blood cells (RBC) without evidence of any cross-reaction with SARS-CoV-2 antigens. This IgM lambda alloantibody was unmutated and unswitched. Here, we describe for the first time the emergence of a bystander de novo natural alloantibody against RBCs in a severe COVID-19 patient, highlighting the extra-follicular humoral response reported in these cases.

Keywords

COVID-19
Transfusion
Alloantibody
M-antigen

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1

contributed equally to this work as co-first authors.