Clinical Characteristic of Thoracic Malignancy Patients with Coronavirus Disease 2019 Related to Mitigation Strategy in Dharmais National Cancer Center Hospital, Indonesia

Arif Hanafi; Noorwati Soetandyo; Achmad Mulawarman Jayusman; Leovinna Widjaja; Fifi Dwijayanti; Priscillia Imelda

doi:10.3889/oamjms.2021.6525

Authors

Arif Hanafi Department of Pulmonology https://orcid.org/0000-0002-1121-0180
Noorwati Soetandyo Department of Medical Hematology-Oncology
Achmad Mulawarman Jayusman Department of Pulmonology
Leovinna Widjaja Department of Research and Development
Fifi Dwijayanti Department of Research and Development, Dharmais National Cancer Center, Jakarta, Indonesia https://orcid.org/0000-0002-1392-0602
Priscillia Imelda Department of Pulmonology, Dharmais National Cancer Center, Jakarta, Indonesia https://orcid.org/0000-0003-2049-1284

DOI:

https://doi.org/10.3889/oamjms.2021.6525

Keywords:

Thoracic malignancy, Coronavirus disease 2019, Disease severity, Mitigation

Abstract

Aim: To describe the clinical data and disease severity of thoracic malignancy patients with COVID-19 and its relation to the mitigation process at the Dharmais National Cancer Center, Indonesia.

Methods: Total 5256 cancer patients registered from May 2020 to March 2021. There were 681 cancer patients diagnosed with COVID-19. Forty-five thoracic malignancy patients were enrolled. Data from medical records were obtained at the Dharmais Cancer Hospital, then analyzed using SPSS version 25. Comparative result was considered significant, as p-value < 0.05.

Results: There were 12.9% of total patients registered infected by COVID-19, which 6% with thoracic malignancy dominated by Non-small cell lung carcinoma (57.8%). Patients who have asymptomatic (31.1%), mild (13.3%), and moderate COVID-19 disease (8.9%) were alive. Patient with severe disease (46.7%) tend to deteriorate. Neutrophilia (mean 78.0%), lymphopenia (mean 13.0%), high neutrophil to lymphocyte ratio (mean 13.1), hyperuricemia (mean 31.6 mg/dL), high fibrinogen (mean 521.7 mg/dL), and high d-dimer (mean 3821.6 ng/mL) were significantly associated with disease severity (p-value < 0.05).

Conclusions: Only small number of cancer patients affected by COVID-19 and mostly do not progress to severe disease, showing the strict mitigation strategy was successful. Severe disease patients have a poor prognosis, with neutrophilia, lymphopenia, high neutrophil to lymphocyte ratio, hyperuricemia, high fibrinogen, and high d-dimer may be valuable for predicting poor prognosis.

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