Elsevier

Vaccine

Volume 41, Issue 2, 9 January 2023, Pages 290-293
Vaccine

Short communication
Effectiveness of vaccines in preventing hospitalization due to COVID-19: A multicenter hospital-based case-control study, Germany, June 2021 to January 2022

https://doi.org/10.1016/j.vaccine.2022.11.065Get rights and content
Under a Creative Commons license
open access

Highlights

  • This study assesses detailed first-hand data and therefore provides a very high data quality.

  • Detailed interviews, abstraction of medical records and laboratory analyses were combined to obtain comprehensive data sets.

  • More than half of the cases (58 %) were not vaccinated at all, compared to 11 % of the controls.

  • The vaccine effictiveness to prevent severe disease in the Delta wave was 89 % overall for two doses and 98 % for three doses.

Abstract

We included 852 patients in a prospectively recruiting multicenter matched case-control study in Germany to assess vaccine effectiveness (VE) in preventing COVID-19-associated hospitalization during the Delta-variant dominance. The two-dose VE was 89 % (95 % CI 84–93 %) overall, 79 % in patients with more than two comorbidities and 77 % in adults aged 60–75 years. A third dose increased the VE to more than 93 % in all patient-subgroups.

Keywords

COVID-19
Vaccine effectiveness
Hospitalization
Case-control study
SARS-CoV-2
Delta

Data availability

Data will be made available on request.

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Equal contribution.