A Novel and Water-Soluble Material for Coronavirus Inactivation from Oseltamivir in the Cavity of Methyl and Sulfated-β-Cyclodextrins Through Inclusion Complexation
39 Pages Posted: 19 Aug 2022
Abstract
A potentially active water-soluble anti-viral agent with lesser toxic material from the Oseltamivir (OTV) has been produced by the sonication method. The formed material has been further characterized by UV-visible, FT-IR, powder XRD, SEM, TEM, TGA/DTA, ROESY, XPS, AFM and etc., The results of DFT analysis have proven that inclusion complexes (ICs) are theoretically and energetically more advantageous models and structures have also been proposed based on the results. Analysis of drug release has been carried out at three pH levels, and it is revealed the analysis is most helpful at acidic pH levels for the ICs with S-CD over H-CD. Over OTV without CDs, OTV:S-CD-ICs exhibited a very less cytotoxic ability on cancer cell lines than ICs with M-CD. ICs enhanced the viral inactivation nature of OTV. This study provides for the first time a full characterization of ICs of OTV with CDs and highlights the impact of complex formation on pharmacological activity.
Note:
Funding Information: We are grateful for the support from the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (2021R1F1A106156611).
Declaration of Interests: There are no conflicts of interest to declare.
Keywords: Oseltamivir, Modified cyclodextrins, Water-soluble inclusion materials, drug delivery, Coronavirus inactivation
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