A Novel and Water-Soluble Material for Coronavirus Inactivation from Oseltamivir in the Cavity of Methyl and Sulfated-β-Cyclodextrins Through Inclusion Complexation

39 Pages Posted: 19 Aug 2022

See all articles by Rajaram Rajamohan

Rajaram Rajamohan

Yeungnam University

Sonaimuthu Mohandoss

Yeungnam University

Sekar Ashok Kumar

Kwangwoon University

Eun Ha Choi

Kwangwoon University

Fatiha Madi

8 Mai 1945 – Guelma University

Nouar Leila

8 Mai 1945 – Guelma University

Yong Rok Lee

Yeungnam University

Abstract

A potentially active water-soluble anti-viral agent with lesser toxic material from the Oseltamivir (OTV) has been produced by the sonication method. The formed material has been further characterized by UV-visible, FT-IR, powder XRD, SEM, TEM, TGA/DTA, ROESY, XPS, AFM and etc., The results of DFT analysis have proven that inclusion complexes (ICs) are theoretically and energetically more advantageous models and structures have also been proposed based on the results. Analysis of drug release has been carried out at three pH levels, and it is revealed the analysis is most helpful at acidic pH levels for the ICs with S-CD over H-CD. Over OTV without CDs, OTV:S-CD-ICs exhibited a very less cytotoxic ability on cancer cell lines than ICs with M-CD. ICs enhanced the viral inactivation nature of OTV. This study provides for the first time a full characterization of ICs of OTV with CDs and highlights the impact of complex formation on pharmacological activity.

Note:

Funding Information: We are grateful for the support from the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (2021R1F1A106156611).

Declaration of Interests: There are no conflicts of interest to declare.

Keywords: Oseltamivir, Modified cyclodextrins, Water-soluble inclusion materials, drug delivery, Coronavirus inactivation

Suggested Citation

Rajamohan, Rajaram and Mohandoss, Sonaimuthu and Ashok Kumar, Sekar and Choi, Eun Ha and Madi, Fatiha and Leila, Nouar and Lee, Yong Rok, A Novel and Water-Soluble Material for Coronavirus Inactivation from Oseltamivir in the Cavity of Methyl and Sulfated-β-Cyclodextrins Through Inclusion Complexation. Available at SSRN: https://ssrn.com/abstract=4194443 or http://dx.doi.org/10.2139/ssrn.4194443

Rajaram Rajamohan (Contact Author)

Yeungnam University ( email )

Daedong street
Kyongsan, 712-749
Korea, Republic of (South Korea)

Sonaimuthu Mohandoss

Yeungnam University ( email )

Daedong street
Kyongsan, 712-749
Korea, Republic of (South Korea)

Sekar Ashok Kumar

Kwangwoon University ( email )

Seoul 139-701
Korea, Republic of (South Korea)

Eun Ha Choi

Kwangwoon University ( email )

Seoul 139-701
Korea, Republic of (South Korea)

Fatiha Madi

8 Mai 1945 – Guelma University ( email )

Nouar Leila

8 Mai 1945 – Guelma University ( email )

Yong Rok Lee

Yeungnam University ( email )

Daedong street
Kyongsan, 712-749
Korea, Republic of (South Korea)

Do you have negative results from your research you’d like to share?

Paper statistics

Downloads
28
Abstract Views
190
PlumX Metrics