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Licensed Unlicensed Requires Authentication Published by De Gruyter January 13, 2022

Optimizing effectiveness of COVID-19 vaccination: will laboratory stewardship play a role?

  • Francesco Broccolo ORCID logo EMAIL logo

Corresponding author: Francesco Broccolo, Department of Medicine and Surgery, School of Medicine, University of Milan-Bicocca, Monza, Italy; and Cerba HealthCare Italia, Milan, Italy, E-mail:

  1. Research funding: None declared.

  2. Author contributions: Single author contribution.

  3. Competing interests: The author declares that he has no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

References

1. Lippi, G, Henry, BM, Plebani, M. Optimizing effectiveness of COVID-19 vaccination: will laboratory stewardship play a role? Clin Chem Lab Med 2021;59:1885–8. https://doi.org/10.1515/cclm-2021-0972.Search in Google Scholar PubMed

2. Feng, S, Phillips, DJ, White, T, Sayal, H, Aley, PK, Bibi, S, et al.. Correlates of protection against symptomatic and asymptomatic. SARS-CoV-2 infection. Nat Med 2021;27:2032–40. https://doi.org/10.1038/s41591-021-01540-1.Search in Google Scholar PubMed PubMed Central

3. Planas, D, Veyer, D, Baidaliuk, A, Staropoli, I, Guivel-Benhassine, F, Rajah, MM, et al.. Reduced sensitivity of SARS-CoV-2 variant delta to antibody neutralization. Nature 2021;596:276–80. https://doi.org/10.1038/s41586-021-03777-9.Search in Google Scholar PubMed

4. Planas, D, Saunders, N, Maes, P, Benhassine, FG, Planchais, C, Porrot, F, et al.. Considerable escape of SARS-CoV-2 omicron to antibody neutralization. bioRxiv. https://doi.org/10.1101/2021.12.14.472630, in press.10.1101/2021.12.14.472630Search in Google Scholar

5. Rydyznski Moderbacher, C, Ramirez, SI, Dan, JM, Grifoni, A, Hastie, KM, Weiskopf, D. Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity. Cell 2020;183:996–1012. https://doi.org/10.1016/j.cell.2020.09.038.e19.Search in Google Scholar

6. Khoury, DS, Cromer, D, Reynaldi, A, Schlub, TE, Wheatley, AK, Juno, JA, et al.. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nat Med 2021;27:1205–11. https://doi.org/10.1038/s41591-021-01377-8.Search in Google Scholar PubMed

7. Gilbert, PB, Montefiori, DC, McDermot, AB, Fong, Y, Benkeser, D, Deng, W, et al.. Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy trial. Science 2021. https://doi.org/10.1126/science.abm3425.Search in Google Scholar PubMed PubMed Central

8. Lippi, G, Adeli, K, Plebani, M. Commercial immunoassays for detection of anti-SARS-CoV-2 spike and RBD antibodies: urgent call for validation against new and highly mutated variants. Clin Chem Lab Med 2021. https://doi.org/10.1515/cclm-2021-1287.Search in Google Scholar PubMed

9. Grifoni, A, Weiskopf, D, Ramirez, SI, Mateus, J, Dan, JM, Moderbacher, CR. Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals. Cell 2020;181:1489–501. https://doi.org/10.1016/j.cell.2020.05.015.e15.Search in Google Scholar

10. Murugesan, K, Jagannathan, P, Pham, TD, Pandey, S, Bonilla, HF, Jacobson, K, et al.. Interferon-gamma release assay for accurate detection of SARS-CoV-2 T cell response. Clin Infect Dis. 2021;73:e3130–2. https://doi.org/10.1093/cid/ciaa1537.Search in Google Scholar PubMed PubMed Central

Received: 2021-12-29
Accepted: 2021-12-30
Published Online: 2022-01-13
Published in Print: 2022-02-23

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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