Elsevier

Indian Journal of Medical Microbiology

Volume 41, January–February 2023, Pages 1-4
Indian Journal of Medical Microbiology

Case Report
Cytomegalovirus reactivation in a SARS-CoV-2 infected woman experiencing fetal demise in the first trimester with fetal trisomy 21: A case report

https://doi.org/10.1016/j.ijmmb.2022.12.002Get rights and content

Highlights

  • Reactivation of other common viral infections is likely to occur in Covid-19 positive pregnant women.

  • Role of genetic factors in pregnancy losses should be ruled out in all Covid-19 positive mothers before labeling SARS-CoV-2 virus infection as a cause of fetal demise.

  • Vertical transmission of SARS-CoV-2 is not always seen during pregnancy in all Covid-19 positive mothers.

Abstract

Cytomegalovirus (CMV) is the most common cause of congenital viral infections. Women seropositive for CMV prior to pregnancy can develop a non-primary CMV infection. Here, we present a case of first trimester pregnancy loss during active SARS-CoV-2 infection. There was no evidence of SARS-CoV-2 RNA in placenta and fetal tissue, but there was presence of congenital cytomegalovirus infection by nested PCR. To the best of our knowledge, this is the first report demonstrating association of early congenital CMV infection due to reactivation and fetal demise in a SARS-CoV-2 positive woman with fetal trisomy 21.

Keywords

Congenital cytomegalovirus infection
SARS-CoV-2
Trisomy-21

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