Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination

Masanobu Tanemoto; Ryosuke Oda; Yuichiro Toyama; Hirohiko Shizukawa; Kazuki Yokokawa; Taro Saito; Syuuichirou Suzuki; Akihiro Matsumura; Shin Hisahara

doi:10.2169/internalmedicine.0404-22

This article has now been updated. Please use the final version.

Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination

Masanobu Tanemoto, Ryosuke Oda, Yuichiro Toyama, Hirohiko Shizukawa, Kazuki Yokokawa, Taro Saito, Syuuichirou Suzuki, Akihiro Matsumura, Shin Hisahara

Author information

Masanobu Tanemoto
Department of Neurology, Sapporo Medical University, School of Medicine, Japan
Ryosuke Oda
Department of Neurology, Sapporo Kosei General Hospital, Japan
Yuichiro Toyama
Department of Neurology, Sapporo Kosei General Hospital, Japan
Hirohiko Shizukawa
Department of Neurology, Sapporo Kosei General Hospital, Japan
Kazuki Yokokawa
Department of Neurology, Sapporo Medical University, School of Medicine, Japan
Taro Saito
Department of Neurology, Sapporo Medical University, School of Medicine, Japan
Syuuichirou Suzuki
Department of Neurology, Sapporo Medical University, School of Medicine, Japan
Akihiro Matsumura
Department of Neurology, Sapporo Medical University, School of Medicine, Japan
Shin Hisahara
Department of Neurology, Sapporo Medical University, School of Medicine, Japan

Keywords: anti-signal recognition particle antibody, immune-mediated necrotizing myopathy, myopathy, SARS-CoV-2, vaccine

JOURNAL OPEN ACCESS Advance online publication

Article ID: 0404-22

DOI https://doi.org/10.2169/internalmedicine.0404-22

The final version of this article is now available: Vol. 61 (2022), No. 23 pp. 3605-3609

Details

Abstract

A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, and a blood examination showed prominent elevation of creatinine kinase. Magnetic resonance imaging (MRI) revealed a high signal intensity in the thigh muscles on short-tau inversion recovery images, and antibody testing revealed positive findings for anti-signal recognition particle (SRP) antibody. Thus, anti-SRP antibody-positive immune-mediated myopathy was diagnosed. We initiated immunotherapy, and she was ultimately able to walk stably.

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