puc-header

Identification of Distinct Immune Cells Associated with Various Clinical Presentations of COVID-19

55 Pages Posted: 5 Aug 2021 Publication Status: Review Complete

See all articles by Xiaorui Wang

Xiaorui Wang

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Han Bai

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Junpeng Ma

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Hongyu Qin

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Tingting Jiang

LC-BIO TECHNOLOGIES (HANGZHOU) CO., LTD.

Weikang Mao

LC-BIO TECHNOLOGIES (HANGZHOU) CO., LTD.

Qiqi Zeng

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Fang Hu

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Yan Teng

Xi'an Jiaotong University (XJTU) - Department of Critical Care Medicine

Lin Fan

Xi'an Jiaotong University (XJTU) - Department of General Surgery

Yang Zhao

Wuhan University - Department of Respiratory and Critical Care Medicine

Xiaobei Chen

Wuhan University - Department of Infectious Diseases

Xin Qi

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Mengyang Li

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Meng Jiang

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Jiao Xu

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Qindong Shi

Xi'an Jiaotong University (XJTU) - Department of Critical Care Medicine

Zhihong Shi

Xi'an Jiaotong University (XJTU) - Department of Respiratory Medicine

Jiajia Ma

Xi'an Jiaotong University (XJTU) - Department of Critical Care Medicine

Jing Wu

Xi'an Jiaotong University (XJTU) - Department of Surgical Oncology

Jianfeng Han

Xi'an Jiaotong University (XJTU) - Department of Neurology

Yankui Wang

Wuhan University - Dialysis Center

Jingcan Hao

Xi'an Jiaotong University (XJTU) - Cancer Center

Xi Ding

Xi'an Jiaotong University (XJTU) - Department of Endocrinology

Yue Wang

Xi'an Jiaotong University (XJTU) - Department of Endocrinology

Yuanrui Liu

LC-BIO TECHNOLOGIES (HANGZHOU) CO., LTD.

Tianlong Huang

LC-BIO TECHNOLOGIES (HANGZHOU) CO., LTD.

Chao Fang

LC-BIO TECHNOLOGIES (HANGZHOU) CO., LTD.

Changli Ge

LC-BIO TECHNOLOGIES (HANGZHOU) CO., LTD.

Dong Li

Wuhan University - Department of Clinical Laboratory

Ke Hu

Wuhan University - Department of Respiratory and Critical Care Medicine

Binghong Zhang

Wuhan University - Renmin Hospital

Xianwen Ren

Peking University - Biomedical Pioneering Innovation Center (BIOPIC)

Baojun Zhang

Xi'an Jiaotong University (XJTU) - Department of Pathogenic Microbiology and Immunology

Bingyin Shi

Xi'an Jiaotong University (XJTU) - Department of Endocrinology

Chengsheng Zhang

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

More...

Abstract

The cell-mediated protective and pathogenic immune responses to SARS-CoV-2 infection remain largely unknown. Here, we identified 76 distinct cell subsets in the PBMC samples that were associated with various clinical presentations of COVID-19 using scRNA-seq technology coupled with a deep and comprehensive analysis of unique cell surface markers and differentially expressed genes. Notable cell subsets include (NCAM1hiCD160+)NK and (TRAV1-2+CD8+)MAIT cells increased in the asymptomatic subjects, (LAG3+CD160+CD8+)NKT cells increased in the symptomatic patients, (CD68-CSF1R-IL1BhiCD14+)classical monocytes associated with age and disease severity, (CD33-HLA-DMA-CD14+)classical monocytes and (CLEC10A-S100A9lo)pDC associated with the viral persistence, neutrophils and (CD68-CSF1R-IL1BhiCD14+ )classical monocytes dramatically increased in a fatal patient, whereas (LAG3+CD160+CD8+)NKT and (FOXP3+IL2RA+IL7R+CD4+)Treg cells markedly increased in a patient with humoral immunodeficiency. The GO and KEGG analyses identified enriched pathways related to immune responses, inflammation, apoptosis and other processes. These findings may enhance our understanding of the immunopathogenesis of COVID-19 and help develop novel strategies against SARS-CoV-2 infection.

Funding Information: This study is supported in part by the Department of Science and Technology of Shaanxi Province (Grant No. 2020ZDXM2-SF-02) (CZ and BS) and the operational funds from The First Affiliated Hospital of Xi’an Jiaotong University (CZ and BS).

Declaration of Interests: The authors declare that they have no competing financial interests.

Keywords: SARS-CoV-2, COVID-19, asymptomatic infection, disease severity, viral persistence, single-cell RNA sequencing (scRNA-seq), PBMCs

Suggested Citation

Wang, Xiaorui and Bai, Han and Ma, Junpeng and Qin, Hongyu and Jiang, Tingting and Mao, Weikang and Zeng, Qiqi and Hu, Fang and Teng, Yan and Fan, Lin and Zhao, Yang and Chen, Xiaobei and Qi, Xin and Li, Mengyang and Jiang, Meng and Xu, Jiao and Shi, Qindong and Shi, Zhihong and Ma, Jiajia and Wu, Jing and Han, Jianfeng and Wang, Yankui and Hao, Jingcan and Ding, Xi and Wang, Yue and Liu, Yuanrui and Huang, Tianlong and Fang, Chao and Ge, Changli and Li, Dong and Hu, Ke and Zhang, Binghong and Ren, Xianwen and Zhang, Baojun and Shi, Bingyin and Zhang, Chengsheng, Identification of Distinct Immune Cells Associated with Various Clinical Presentations of COVID-19. Available at SSRN: https://ssrn.com/abstract=3900124 or http://dx.doi.org/10.2139/ssrn.3900124
This version of the paper has not been formally peer reviewed.

Xiaorui Wang

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Xi'an
China

Han Bai

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Xi'an
China

Junpeng Ma

Xi'an Jiaotong University (XJTU) - Precision Medicine Center ( email )

Xi'an
China

Hongyu Qin

Xi'an Jiaotong University (XJTU) - Precision Medicine Center ( email )

Xi'an
China

Tingting Jiang

LC-BIO TECHNOLOGIES (HANGZHOU) CO., LTD.

Hanghzhou
China

Weikang Mao

LC-BIO TECHNOLOGIES (HANGZHOU) CO., LTD. ( email )

Hanghzhou
China

Qiqi Zeng

Xi'an Jiaotong University (XJTU) - Precision Medicine Center ( email )

Xi'an
China

Fang Hu

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Xi'an
China

Yan Teng

Xi'an Jiaotong University (XJTU) - Department of Critical Care Medicine

China

Lin Fan

Xi'an Jiaotong University (XJTU) - Department of General Surgery

China

Yang Zhao

Wuhan University - Department of Respiratory and Critical Care Medicine

Wuhan
China

Xiaobei Chen

Wuhan University - Department of Infectious Diseases ( email )

Wuhan
China

Xin Qi

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Xi'an
China

Mengyang Li

Xi'an Jiaotong University (XJTU) - Precision Medicine Center ( email )

Xi'an
China

Meng Jiang

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Xi'an
China

Jiao Xu

Xi'an Jiaotong University (XJTU) - Precision Medicine Center

Xi'an
China

Qindong Shi

Xi'an Jiaotong University (XJTU) - Department of Critical Care Medicine ( email )

China

Zhihong Shi

Xi'an Jiaotong University (XJTU) - Department of Respiratory Medicine

China

Jiajia Ma

Xi'an Jiaotong University (XJTU) - Department of Critical Care Medicine

China

Jing Wu

Xi'an Jiaotong University (XJTU) - Department of Surgical Oncology

China

Jianfeng Han

Xi'an Jiaotong University (XJTU) - Department of Neurology ( email )

China

Yankui Wang

Wuhan University - Dialysis Center ( email )

China

Jingcan Hao

Xi'an Jiaotong University (XJTU) - Cancer Center ( email )

Xi'an
China

Xi Ding

Xi'an Jiaotong University (XJTU) - Department of Endocrinology

China

Yue Wang

Xi'an Jiaotong University (XJTU) - Department of Endocrinology ( email )

Xi'an, Shannxi 710061
China

Yuanrui Liu

LC-BIO TECHNOLOGIES (HANGZHOU) CO., LTD. ( email )

Hanghzhou
China

Tianlong Huang

LC-BIO TECHNOLOGIES (HANGZHOU) CO., LTD.

Hanghzhou
China

Chao Fang

LC-BIO TECHNOLOGIES (HANGZHOU) CO., LTD.

Hanghzhou
China

Changli Ge

LC-BIO TECHNOLOGIES (HANGZHOU) CO., LTD. ( email )

Hanghzhou
China

Dong Li

Wuhan University - Department of Clinical Laboratory ( email )

China

Ke Hu

Wuhan University - Department of Respiratory and Critical Care Medicine ( email )

Wuhan
China

Binghong Zhang

Wuhan University - Renmin Hospital ( email )

Wuhan, Hubei 442000
China

Xianwen Ren

Peking University - Biomedical Pioneering Innovation Center (BIOPIC) ( email )

Beijing, 100871
China

Baojun Zhang

Xi'an Jiaotong University (XJTU) - Department of Pathogenic Microbiology and Immunology ( email )

China

Bingyin Shi

Xi'an Jiaotong University (XJTU) - Department of Endocrinology ( email )

Xi'an, Shannxi 710061
China

Chengsheng Zhang (Contact Author)

Xi'an Jiaotong University (XJTU) - Precision Medicine Center ( email )

Xi'an
China

Click here to go to Cell.com

Paper statistics

Downloads
17
Abstract Views
550
PlumX Metrics