Review articleContribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions
Graphical abstract
Abbreviations
ADCC
antibody-dependent cellular cytotoxicity
ACE2
angiotensin-converting enzyme 2
ADAM17
ADAM metallopeptidase domain 17
ALI
acute lung injury
ARDS
acute respiratory distress syndrome
CD
cluster of differentiation
CRP
C-reactive protein
CTL
cytotoxic T lymphocyte
IFN
interferon
IRF
interferon regulatory factor
MCP-1
monocyte chemoattractant protein-1
MDA5
melanoma differentiation-associated protein 5
MERS-CoV
Middle East respiratory syndrome-related coronavirus
MHC
major histocompatibility complex
mTOR
mammalian target of rapamycin
NF-κB
nuclear factor-κB
NLRP3
Nod-like receptor protein 3
PAMPs
pathogen-associated molecular patterns
PBMCs
peripheral blood mononuclear cells
pDCs
plasmacytoid dendritic cells
PRRs
pattern recognition receptors
PRRSV
porcine reproductive and respiratory syndrome virus
RIG-I
retinoic acid-inducible gene I
SARS-CoV
severe acute respiratory syndrome-related coronavirus
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
siRNA
small interfering RNA
STAT
signal transducers and activators of transcription
TMPRSS2
transmembrane serine protease 2
Treg
regulatory T cells
WHO
World Health Organization
Keywords
COVID-19
SARS-CoV-2
Macrophages
Monocytes
Pathogenesis
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