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Endocrine Abstracts (2022) 81 RC5.1 | DOI: 10.1530/endoabs.81.RC5.1

ECE2022 Rapid Communications Rapid Communications 5: Diabetes, Obesity, Metabolism and Nutrition 2 (8 abstracts)

Vascular cellular adhesion molecules are high during one year after acute COVID-19 infection in patients with type 2 diabetes

Anna Alieva , Feruza Khaydarova , Khurshida Sultonova , Khurshida Kamalova , Vasila Talenova & Iroda Tajieva


Republican Specialized Scientific and Practical Centre of Endocrinology, Tashkent, Uzbekistan


Background: Molecules of adhesion is a group of glycoproteins which expressed in cell surface and play pivotal role in inflammatory and oncological processes, and new studies show increasing of adhesion molecules within 6-12 hours after COVID-19 contamination, peaking in 24 hours. High level of adhesion molecules is a predictor of disease severity and mortality rate.

Aim: Of our study was to evaluate the level of VCAM-1 in patients with type 2 diabetes mellitus in one year after COVID-19 infection.

Materials and methods: We studied 166 type 2 diabetes patients who had COVID-19 in 2020 in 3-15 months (average, one year) after the acute infection. VCAM-1 was tested using Human ELISA Kit assay (Elabscience) in the laboratory of the Republican centre of Endocrinology. Statistic analysis was performed using STATA v.16.0.

Results: The level of VCAM-1 stayed increased up to 15 months after the COVID-19 onset. It was significantly lower in patients regularly taking rivaroxaban (174.65, 95%CI 134.2-215.1 vs 618.12, 95%CI 542.04-694.19), beta-blockers (466.39, 95% CI 373.91-558.87 vs 676.35, 95% CI 578.15-774.56), ACE inhibitors (417.76, 95% CI 314.72-520.81 vs 674.82, 95% CI 586.86-762.77), statins (318.65, 95% CI 238.54-398.75 vs 717.02, 95% CI 630.12-803.91), and fibrates (235.35, 95% CI 133.96-336.75 vs 902.53, 95% CI 812.43-992.63) and had no difference depending on glucose lowering therapy, aspirin or clopidogrel, or coagulogram. Interestingly, VCAM-1 level was significantly lower in those patients who received dexamethasone (423.76, 95% CI 332.37-515.14 vs 664.26, 95% CI 572.79-755.72) and remdesivir (244.29, 95% CI 160.25-328.32 vs 666.07, 95% CI 586.89-745.25), but not favipiravir during the acute COVID-19. Patients who had arterial hypertension and did not take regular antyhypertensive therapy had significantly higher levels of VCAM-1 (851.09, 95% CI 597.77-1104.42 vs 527.93, 95% CI 461.99-593.86).

Conclusion: Endothelial dysfunction may be preserved up to one year after COVID-19, and patients with type 2 diabetes should be monitored closely for post-COVID vascular complications.

Key words: Diabetes, COVID-19, vascular adhesion molecules, endothelial dysfunction

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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