Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter October 22, 2021

Value of hypocalcemia and thromboinflammatory biomarkers for prediction of COVID-19 severity during the second wave: were all the waves the same?

  • Luis García de Guadiana-Romualdo ORCID logo EMAIL logo , Verónica Ramos-Arenas , María Dolores Rodríguez Mulero , Marta Hernández Olivo , Valerio Campos-Rodríguez , María Galindo Martínez , María Salomé Ros Braquehais , Luciano Consuegra-Sánchez , Mercedes González Morales and María Dolores Albaladejo-Otón

Corresponding author: Luis García de Guadiana-Romualdo, Laboratory Medicine Department, Hospital Universitario Santa Lucía, Calle Mezquita s/n, Paraje Los Arcos, CP 30202, Cartagena, Spain, E-mail:

  1. Research funding: None declared.

  2. Author contributions: LGGR designed the study, analyzed the data and wrote the manuscript. LCS provided statistical advice. VRA, MGM and MDAO collected the laboratory investigations. MDRM, MHO, MGM, MSRB and VCR contributed to the enrolment of patients and clinical data collection. All authors have reviewed critically the manuscript and have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Ethical approval and informed consent: The study was approved by the local Ethics Committee (E.O.2020-38 LAB2-COVID19) and performed under a waiver of informed consent and in accordance with the Declaration of Helsinki ethical guidelines.

References

1. Lippi, G, Plebani, M. The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks. Clin Chem Lab Med 2020;58:1063–9. https://doi.org/10.1515/cclm-2020-0240.Search in Google Scholar PubMed

2. Bohn, MK, Lippi, G, Horvath, A, Sethi, S, Koch, D, Ferrari, M, et al.. Molecular, serological, and biochemical diagnosis and monitoring of COVID-19: IFCC taskforce evaluation of the latest evidence. Clin Chem Lab Med 2020;58:1037–52. https://doi.org/10.1515/cclm-2020-0722.Search in Google Scholar PubMed

3. di Filippo, L, Doga, M, Frara, S, Giustina, A. Hypocalcemia in COVID-19: prevalence, clinical significance and therapeutic implications. Rev Endocr Metab Disord 2021;13:1–10. https://doi.org/10.1007/s11154-021-09655-z.Search in Google Scholar PubMed PubMed Central

4. di Filippo, L, Formenti, AM, Giustina, A. Hypocalcemia: the quest for the cause of a major biochemical feature of COVID-19. Endocrine 2020;70:463–4. https://doi.org/10.1007/s12020-020-02525-9.Search in Google Scholar PubMed PubMed Central

5. di Filippo, L, Frara, S, Giustina, A. The emerging osteo-metabolic phenotype of COVID-19: clinical and pathophysiological aspects. Nat Rev Endocrinol 2021;17:445–6. https://doi.org/10.1038/s41574-021-00516-y.Search in Google Scholar PubMed PubMed Central

6. di Filippo, L, Allora, A, Locatelli, M, Rovere Querini, P, Frara, S, Banfi, G, et al.. Hypocalcemia in COVID-19 is associated with low vitamin D levels and impaired compensatory PTH response. Endocrine 2021;29:1–7. https://doi.org/10.1007/s12020-021-02882-z.Search in Google Scholar PubMed PubMed Central

7. Yang, C, Ma, X, Wu, J, Han, J, Zheng, Z, Duan, H, et al.. Low serum calcium and phosphorus and their clinical performance in detecting COVID-19 patients. J Med Virol 2021;93:1639–51. https://doi.org/10.1002/jmv.26515.Search in Google Scholar PubMed

8. Torres, B, Alcubilla, P, González-Cordón, A, Inciarte, A, Chumbita, M, Cardozo, C, et al.. COVID19 Hospital Clínic Infectious Diseases Research Group. Impact of low serum calcium at hospital admission on SARS-CoV-2 infection outcome. Int J Infect Dis 2021;104:164–8. https://doi.org/10.1016/j.ijid.2020.11.207.Search in Google Scholar PubMed PubMed Central

9. Siniorakis, EE, Arvanitakis, SG, Elkouris, MJ. Letter to the Editor in response to article: hypocalcemia is associated with severe COVID-19: a systematic review and meta-analysis (Martha et al.). Diabetes Metab Syndr 2021;15:1059–60. https://doi.org/10.1016/j.dsx.2021.03.009.Search in Google Scholar PubMed PubMed Central

10. Singh, VP, Khatua, B, El-Kurdi, B, Rood, C. Mechanistic basis and therapeutic relevance of hypocalcemia during severe COVID-19 infection. Endocrine 2020;70:461–2. https://doi.org/10.1007/s12020-020-02530-y.Search in Google Scholar PubMed PubMed Central

11. Di Filippo, L, Formenti, AM, Rovere-Querini, P, Carlucci, M, Conte, C, Ciceri, F, et al.. Hypocalcemia is highly prevalent and predicts hospitalization in patients with COVID-19. Endocrine 2020;68:475–8. https://doi.org/10.1007/s12020-020-02383-5.Search in Google Scholar PubMed PubMed Central

12. Rodríguez-Núñez, N, Gude, F, Lama, A, Rábade, C, Varela, A, Abelleira, R, et al.. Health indicators in hospitalized patients with SARS-CoV-2 pneumonia: a comparison between the first and second wave. Arch Bronconeumol (Engl Ed) 2021;23:S0300-2896(21)00110-1. https://doi.org/10.1016/j.arbres.2021.03.012.Search in Google Scholar PubMed

13. Kothapalli, KSD, Park, HG, Brenna, JT. Polyunsaturated fatty acid biosynthesis pathway and genetics. Implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19. Prostaglandins Leukot Essent Fatty Acids 2020;162:102183. https://doi.org/10.1016/j.plefa.2020.102183.Search in Google Scholar PubMed PubMed Central

Received: 2021-09-09
Accepted: 2021-10-11
Published Online: 2021-10-22
Published in Print: 2022-01-27

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 18.4.2024 from https://www.degruyter.com/document/doi/10.1515/cclm-2021-0996/html
Scroll to top button