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Cardiac Imaging Phenotype in Patients with Coronavirus Disease 2019 – COCARDE study: prospective observational study
Olivier Lairez;
Virginie Blanchard;
Laurent Balardy;
Fanny Vardon-Bounes;
Stéphanie Cazalbou;
Stéphanie Ruiz;
Samia Collot;
Valérie Houard;
Yves Rolland;
Jean-Marie Conil;
Vincent Minville
ABSTRACT
Background – The effects of SARS-Cov-2 (COVID-19) on the myocardium and their role in the clinical course of infected patients are still unknown. The severity of SARS-Cov-2 is driven by hyperinflammation and the effects of SARS-Cov-2 on the myocardium may be significant. The present study proposes to use bedside observations and biomarkers to characterize the association COVID-19 with myocardial injury.
Objectives – The aim of the study is to describe the myocardial function and its evolution over the time in patients infected with SARS-COV-2; and to investigate the link between inflammation and cardiac injury.
Design – This prospective, monocentric observational study will enroll 150 patients with suspected or confirmed SARS-COV-2 infection at Toulouse University Hospital, Toulouse, France. Patients admitted in intensive care unit, regular cardiologic ward as well as geriatric ward of our tertiary university hospital will be included during the pandemic period. Blood sampling, electrocardiography, echocardiography, as well as morphometric and demographic data will be prospectively collected.
Implications – A better understanding of the effects of COVID-19 on myocardia function and the links with inflammation would improve patient follow-up and care.
Trial registration – Clinicaltrials.gov NCT04358952
Citation
Please cite as:
Lairez O, Blanchard V, Balardy L, Vardon-Bounes F, Cazalbou S, Ruiz S, Collot S, Houard V, Rolland Y, Conil JM, Minville V
COCARDE Study–Cardiac Imaging Phenotype in Patients With COVID-19: Protocol for a Prospective Observational Study