SARS-CoV-2: an imperative maternal-fetal concern

Zahra Heydarifard; Jila Yavarian; Somayeh Shatizadeh Malekshahi; Sevrin Zadheidar; Talat Mokhtari-Azad; Nazanin Zahra Shafiei-Jandaghi

doi:10.18502/ijm.v13i4.6963

Zahra Heydarifard Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Jila Yavarian Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Somayeh Shatizadeh Malekshahi Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Sevrin Zadheidar Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Talat Mokhtari-Azad Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Nazanin Zahra Shafiei-Jandaghi Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/ijm.v13i4.6963

Keywords: COVID-19; SARS-CoV-2; Pregnancy; Fetus; Vertical transmission

Abstract

Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a newly emerged virus which belongs to Coronaviridae family within the betacoronavirus genus. Previous reports demonstrated that other betacoronaviruses were responsible for adverse outcomes during pregnancy in human. Due to inadequate data, the consequences of a SARS-CoV-2 infection during pregnancy is still a public health concern in the second year of SARS-CoV-2 circulation in human population. Herein, we aimed to review the probable risk of intrauterine vertical transmission of SARS-CoV-2 infection to the fetus, its adverse outcomes during pregnancy for both mother and the fetus and maternal risk factors which affect the severity Coronavirus disease 2019 (COVID-19.